This clinical trial is focused on studying a type of cancer known as soft-tissue sarcoma, which is a cancer that develops in the soft tissues of the body, such as muscles, fat, and blood vessels. The study is specifically looking at cases where the cancer can be surgically removed and has not spread to other parts of the body. The purpose of the study is to see if adding more chemotherapy before surgery can improve outcomes for patients who are at high risk. Chemotherapy is a treatment that uses drugs to kill cancer cells, and in this study, the drugs being used are doxorubicin, dacarbazine, and ifosfamide. These drugs are given through a process called infusion, where the medication is delivered directly into the bloodstream through a vein.

The study will involve several steps. Initially, patients will receive three cycles of chemotherapy with doxorubicin, followed by surgery to remove the tumor. Some patients will receive additional cycles of chemotherapy before surgery to see if this improves their chances of staying cancer-free. After surgery, patients may also receive radiotherapy, which uses high-energy rays to target and kill any remaining cancer cells. The main goal is to see if this approach helps patients live longer without the cancer coming back or spreading.

Throughout the study, doctors will monitor patients closely to see how well the treatment is working and to check for any side effects. The study will last for several years to gather enough information to determine if the intensified chemotherapy approach is beneficial. The results will help doctors understand if this treatment plan can be used to improve the care of patients with high-risk soft-tissue sarcoma in the future.