This clinical trial is focused on studying treatments for locally advanced pancreatic cancer. The study involves a sequence of treatments starting with a combination of medications known as GEMBRAX and FOLFIRINOX. These are chemotherapy treatments that use different drugs to target cancer cells. The medications involved in this study include levoleucovorin disodium, gemcitabine, fluorouracil, paclitaxel albumin-bound, irinotecan hydrochloride trihydrate, and oxaliplatin. After the chemotherapy, patients will receive MRI-guided radiotherapy, which uses magnetic resonance imaging to help direct radiation precisely at the cancer.
The purpose of the study is to evaluate how effective the sequence of chemotherapy treatments is and to assess how well patients tolerate the radiotherapy. Participants will first receive the chemotherapy treatments, followed by the radiotherapy if their cancer has not progressed. The study will monitor patients over a period to see how the cancer responds to the treatments and to check for any side effects.
Throughout the study, the focus will be on understanding the benefits of the treatment sequence and ensuring the safety and well-being of the participants. The study aims to provide valuable information on the effectiveness of combining these treatments for patients with locally advanced pancreatic cancer.
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