Study on Ropivacaine and Lidocaine for Reducing Pain After Tonsil Removal in Patients with Chronic Tonsillitis

3 1 1 1

What is this study about?

This clinical trial is focused on studying the effects of two medications, Ropivacaine and Lidocaine, used as local anesthesia for patients undergoing surgery to remove their tonsils, a procedure known as a tonsillectomy. The study is particularly interested in patients who have Chronic Tonsillitis, which is a persistent inflammation of the tonsils. The main goal of the study is to determine if Ropivacaine is more effective than Lidocaine in reducing pain after the surgery.

Participants in the study will receive either Ropivacaine or Lidocaine during their tonsillectomy. The study will monitor the level of pain experienced by participants after the surgery using a tool called the Visual Analog Scale, which measures pain on a scale from 0 to 10. This will be done several times a day for the first three days after the surgery. The study will also look at how much pain medication participants need during their hospital stay and how quickly they need additional pain relief after the surgery.

The trial will last until the end of 2025, with recruitment of participants expected to start in mid-2025. The study aims to provide valuable information on which local anesthetic is more effective in managing pain after a tonsillectomy, potentially improving recovery experiences for patients with Chronic Tonsillitis.

1 joining the study

Upon joining the study, eligibility is confirmed based on criteria such as being 18 years or older, having chronic tonsillitis, and having a recommendation for a tonsillectomy by an ear, nose, and throat specialist.

2 surgery and initial treatment

The tonsillectomy procedure is performed. During the surgery, local anesthesia is administered using either ropivacaine or lidocaine to manage pain.

The main goal is to determine which anesthetic provides better pain relief after the surgery.

3 postoperative pain assessment

After the surgery, pain levels are measured using a tool called the Visual Analog Scale (VAS), which ranges from 0 (no pain) to 10 (worst pain imaginable).

Pain assessments occur four times daily for the first 72 hours after the surgery, resulting in a total of 12 measurements.

4 inpatient stay and medication

During the hospital stay from Day 1 to Day 4, the amount of pain medication taken is recorded. Two types of pain relief medications are used, but specific names are not provided.

The time taken to first require additional pain medication after surgery is also recorded.

5 post-discharge pain assessment

After being discharged from the hospital, pain levels continue to be assessed using the VAS scale.

These assessments occur four times daily from Day 4 to Day 14, providing a total of 11 days of pain monitoring.

Who Can Join the Study?

  • Must be 18 years or older.
  • Must have Chronic Tonsillitis.
  • Must have a recommendation for a tonsillectomy (surgery to remove the tonsils) from an otorhinolaryngologist (a doctor who specializes in ear, nose, and throat conditions).

Who Cannot Join the Study?

  • Patients with any medical condition other than Chronic Tonsillitis cannot participate.
  • Patients who are not within the age range of 3 to 4 years old cannot participate.
  • Patients who are not part of the specified clinical trial group cannot participate.
  • Patients who are not able to give informed consent or are part of a vulnerable population cannot participate.

Where you can join this trial?

Verified and Recommended Sites

No sites found in this category

Verified Sites

No sites found in this category

Other Sites

Site Name City Country Status
Tpdynkpsdvytca Gksw Zell Am See Austria

Want to learn more about this study or check if you can participate? Contact us.

Trial status

Country Status Recruitment Start
Austria Austria
Recruiting
01.06.2025

Trial locations

Ropivacaine is a medication used to numb a specific area of the body, which helps to reduce pain during and after surgery. In this clinical trial, it is being tested to see if it can better manage pain after a tonsillectomy, which is a surgery to remove the tonsils. The goal is to see if patients experience less pain after the surgery when using ropivacaine compared to another numbing medication.

Lidocaine is another medication used to numb a specific area of the body to help reduce pain. It is commonly used in various medical procedures to make patients more comfortable. In this trial, lidocaine is being compared to ropivacaine to see which one is more effective at reducing pain after a tonsillectomy. The researchers want to find out if lidocaine is less effective, equally effective, or more effective than ropivacaine in managing postoperative pain.

Investigated diseases:

Chronic Tonsillitis – Chronic tonsillitis is a persistent inflammation of the tonsils, which are two lymph nodes located at the back of the throat. This condition is characterized by repeated episodes of sore throat, swollen tonsils, and discomfort in the throat area. Over time, the tonsils may become enlarged and develop small pockets that trap bacteria, leading to bad breath and a constant sore throat. The inflammation can cause difficulty swallowing and may be accompanied by a low-grade fever. Chronic tonsillitis can also lead to the formation of tonsil stones, which are small, hard deposits that form in the tonsils. The condition often results from repeated infections or persistent bacterial presence in the tonsils.

Trial ID:
2025-520820-44-00
Trial Phase:
Therapeutic confirmatory (Phase III)

Other Trials to Consider

  • Study on Phenoxymethylpenicillin for Patients with Severe Streptococcus Group A-Negative Acute Tonsillitis

    Recruiting

    3 1 1 1
    Investigated diseases:
    Investigated drugs:
    Sweden
  • Benzydamine Hydrochloride Lozenges for Non-Streptococcal Pharyngotonsillitis in Children Aged 6 to 11 Years

    Not yet recruiting

    3 1 1 1
    Investigated diseases:
    Investigated drugs:
    Italy