This clinical trial is focused on studying Prosthetic Joint Infection, which can occur after a hip replacement surgery. The trial is called the ABOGRAFT trial and aims to find out if using an antibiotic impregnated bone graft can reduce the risk of infection two years after hip replacement surgery. A bone graft is a procedure where bone material is used to help repair or replace damaged bones. In this study, the bone graft is treated with antibiotics to see if it helps prevent infections.

The antibiotics being tested in this study are Vancomycin and Tobramycin. These are medicines used to treat infections caused by bacteria. The study will compare the effects of the antibiotic-treated bone graft with a placebo-treated bone graft. A placebo is a substance with no active medication, used to compare the effects of the actual treatment. The study will observe if there is a difference in the rate of infections between the two groups over a period of two years.

Participants in the study will receive either the antibiotic-treated bone graft or the placebo-treated bone graft during their hip replacement surgery. The study will monitor the participants for any signs of infection or need for additional surgery in the same hip joint within two years. It will also look at the time and reasons for any further surgeries or implant revisions within two to five years. The study aims to provide valuable information on whether the antibiotic-treated bone graft can effectively reduce the risk of infection after hip replacement surgery.