Azithromycin is an antibiotic medication that helps prevent and treat bacterial infections. It belongs to a group of antibiotics called macrolides and works by stopping the growth of bacteria. In this trial, it is used as a preventive measure against infections that may occur after hysterectomy surgery.

Cefuroxime is an antibiotic that fights bacteria in the body. It belongs to a group of medications called cephalosporin antibiotics. It works by preventing bacteria from building their cell walls, which helps stop infections. In this trial, it is used alone or in combination with azithromycin to prevent post-surgical infections following hysterectomy.

Post-operative Surgical Site Infection – An infection that develops in the area of the surgical incision after a hysterectomy procedure. It can affect either the superficial layers of the skin or extend deeper into the surgical site. The infection typically develops within 30 days after surgery and may be accompanied by redness, swelling, and warmth around the incision site.

Pelvic Organ Infection – An infection that occurs in the pelvic region following gynecological surgery. It can affect various organs in the pelvic area and may develop gradually over several days or weeks after the operation. The condition can involve inflammation of the surrounding tissues in the pelvic cavity.

Urinary Tract Infection – An infection affecting any part of the urinary system, most commonly involving the bladder and urethra. The infection occurs when bacteria enter the urinary tract, causing inflammation and discomfort. Symptoms typically include frequent urination, burning sensation during urination, and cloudy urine.

Post-operative Fever – A sustained elevation in body temperature above 38°C (100.4°F) that persists for more than two days following surgery. This condition represents the body’s response to the surgical procedure or potential post-operative complications. The fever may be accompanied by general discomfort and increased heart rate.