Piperacillin/Tazobactam is a combination antibiotic used to treat a wide variety of bacterial infections. In this clinical trial, it is being used to prevent or treat infections that may occur after surgery, specifically following a procedure called pancreaticoduodenectomy. The trial aims to determine if a 5-day course of this antibiotic is more effective than a shorter course in preventing surgical site infections in patients who have had a biliary stent placed before surgery.

Postoperative Pancreatic Fistula – This condition occurs when there is an abnormal connection that forms between the pancreas and other organs or tissues after surgery, such as a pancreaticoduodenectomy. It results in the leakage of pancreatic fluid, which can lead to inflammation and infection in the surrounding areas. The fistula may cause abdominal pain, fever, and an increase in drainage from surgical sites. Over time, the body may absorb the fluid, or the fistula may close on its own. However, persistent fistulas can lead to further complications if not managed properly.

Bile Leakage – Bile leakage is a condition where bile escapes from the bile ducts into the abdominal cavity, often following surgical procedures like pancreaticoduodenectomy. This leakage can cause irritation and inflammation of the abdominal lining, leading to symptoms such as abdominal pain, nausea, and fever. If not addressed, the leaked bile can lead to infection and abscess formation. The body may reabsorb small amounts of bile, but larger leaks may require intervention to prevent further complications.