Soticlestat is a medication being studied for its long-term safety and tolerability when used as an additional treatment for individuals with Dravet Syndrome or Lennox-Gastaut Syndrome. These are types of epilepsy that are difficult to control. Soticlestat is used alongside other standard treatments to help manage seizures in these conditions.

ASMs (Anti-Seizure Medications) are a group of drugs used to help control seizures in people with epilepsy. In this trial, they are used in combination with soticlestat to see how well they work together in managing seizures for those with Dravet Syndrome or Lennox-Gastaut Syndrome.

Vagus Nerve Stimulation is a therapy that involves using a device to send electrical impulses to the vagus nerve in the neck. This can help reduce the frequency and intensity of seizures in some people with epilepsy. It is used in this trial as part of the standard care alongside soticlestat.

Ketogenic Diet is a high-fat, low-carbohydrate diet that can help control seizures in some people with epilepsy. It is used in this trial as part of the standard care to see how it works with soticlestat in managing seizures.

Modified Atkins Diet is a variation of the ketogenic diet that is also high in fat and low in carbohydrates. It is used in this trial as part of the standard care to evaluate its effectiveness in combination with soticlestat for controlling seizures in individuals with Dravet Syndrome or Lennox-Gastaut Syndrome.

Dravet Syndrome – Dravet Syndrome is a rare, severe form of epilepsy that begins in infancy. It is characterized by prolonged seizures that are often triggered by fever or hot temperatures. As the child grows, other types of seizures may develop, including myoclonic and absence seizures. The condition can also lead to developmental delays, speech impairment, and motor difficulties. Children with Dravet Syndrome may experience behavioral challenges and have an increased risk of sudden unexplained death in epilepsy (SUDEP). The syndrome is often resistant to many types of epilepsy medications.

Lennox-Gastaut Syndrome – Lennox-Gastaut Syndrome is a complex, rare form of epilepsy that typically appears in early childhood. It is marked by multiple types of seizures, including tonic and atonic seizures, which can cause sudden falls. Children with this syndrome often have intellectual disabilities and developmental delays. The condition is known for its resistance to treatment and can significantly impact daily life. Seizures in Lennox-Gastaut Syndrome can be frequent and severe, leading to injuries. The syndrome may also cause behavioral problems and difficulties with learning and social interaction.