Recombinant Zoster Vaccine (RZV) is a vaccine designed to protect against shingles, a painful rash caused by the reactivation of the chickenpox virus. In this trial, the vaccine is being studied to see how well it works in people with rheumatic diseases who have weakened immune systems. The focus is on how the body’s immune system responds to the vaccine, specifically looking at certain antibodies and T cells, which are important parts of the immune system.

JAK Inhibitors (JAKi) are a type of medication used to treat rheumatic diseases by reducing inflammation and the activity of the immune system. In this trial, researchers are studying how these medications affect the immune response to the shingles vaccine. The goal is to understand if taking JAK inhibitors changes how well the vaccine works in people with rheumatic diseases.

Methotrexate is a medication commonly used to treat rheumatic diseases by slowing down the immune system and reducing inflammation. In this trial, Methotrexate is being studied to see how it affects the immune response to the shingles vaccine. Researchers want to know if Methotrexate changes how the body responds to the vaccine in people with rheumatic diseases.

Rheumatoid Arthritis – Rheumatoid arthritis is a chronic inflammatory disorder that primarily affects the joints. It typically begins with inflammation of the synovial membrane, leading to swelling and pain. Over time, the inflammation can cause damage to cartilage and bone within the joint. This damage can result in joint deformity and loss of function. The disease often progresses in a symmetrical pattern, affecting the same joints on both sides of the body. It can also cause systemic symptoms such as fatigue and fever.

Psoriatic Arthritis – Psoriatic arthritis is an inflammatory arthritis associated with psoriasis, a skin condition. It can affect any joint in the body and may cause swelling, pain, and stiffness. The disease can lead to joint damage and deformities if not managed. It often affects the fingers and toes, causing them to swell like sausages, a condition known as dactylitis. Psoriatic arthritis can also cause changes in the nails, such as pitting or separation from the nail bed. The progression of the disease can vary, with periods of remission and flare-ups.

Ankylosing Spondylitis – Ankylosing spondylitis is a type of arthritis that primarily affects the spine, although other joints can be involved. It causes inflammation of the vertebrae, which can lead to severe, chronic pain and discomfort. Over time, the inflammation can lead to the fusion of the vertebrae, resulting in a loss of flexibility and a hunched posture. The disease often begins in the lower back and can progress upwards. It may also affect other areas such as the hips, shoulders, and rib cage. Symptoms can vary in intensity and may come and go.