Ifinatamab deruxtecan (I DXd) is a medication being studied for its potential to treat various types of solid tumors that have come back or spread to other parts of the body. It is designed to target and attach to specific proteins on the surface of cancer cells. Once attached, it delivers a powerful drug directly into the cancer cells, which may help to kill them or stop them from growing. This study aims to see how well this medication works in shrinking tumors and to check if it is safe and tolerable for patients with these types of cancers.

Endometrial Cancer – Endometrial cancer originates in the lining of the uterus, known as the endometrium. It typically begins with abnormal cell growth in this lining, which can form a tumor. As the disease progresses, the cancer cells may invade the uterine wall and spread to nearby organs. In advanced stages, it can metastasize to distant parts of the body. The progression is often marked by symptoms such as abnormal vaginal bleeding or discharge.

Head and Neck Squamous Cell Carcinoma – This type of cancer arises from the squamous cells lining the moist surfaces inside the head and neck. It often begins in areas such as the mouth, throat, or nose. The disease progresses by invading nearby tissues and can spread to lymph nodes in the neck. As it advances, it may affect speech, swallowing, and breathing. The progression is typically associated with symptoms like persistent sore throat, difficulty swallowing, or a lump in the neck.

Pancreatic Ductal Adenocarcinoma – Pancreatic ductal adenocarcinoma is a cancer that forms in the ducts of the pancreas. It usually starts with the abnormal growth of cells in these ducts, leading to tumor formation. The disease progresses by invading nearby tissues and organs, such as the stomach and intestines. In advanced stages, it can spread to distant organs like the liver and lungs. Symptoms often include jaundice, weight loss, and abdominal pain as the disease advances.

Colorectal Cancer – Colorectal cancer begins in the colon or rectum, often starting as a polyp that can become cancerous over time. The disease progresses by growing into the wall of the colon or rectum and potentially spreading to nearby lymph nodes. As it advances, it can metastasize to distant organs, such as the liver or lungs. Symptoms may include changes in bowel habits, blood in the stool, and abdominal discomfort.

Hepatocellular Carcinoma – Hepatocellular carcinoma is a primary liver cancer that originates in the liver cells, known as hepatocytes. It often develops in the context of chronic liver disease, such as cirrhosis or hepatitis. The disease progresses by forming a tumor in the liver, which can grow and invade nearby blood vessels. In advanced stages, it may spread to other parts of the body. Symptoms can include abdominal pain, weight loss, and jaundice as the disease progresses.

Adenocarcinoma of Esophagus, Gastroesophageal Junction, and Stomach – This cancer originates in the glandular cells lining the esophagus, gastroesophageal junction, or stomach. It typically begins with abnormal cell growth, forming a tumor in these areas. The disease progresses by invading deeper layers of the esophagus or stomach wall and can spread to nearby lymph nodes. In advanced stages, it may metastasize to distant organs. Symptoms often include difficulty swallowing, weight loss, and stomach pain.

Urothelial Carcinoma – Urothelial carcinoma, also known as transitional cell carcinoma, primarily affects the bladder but can also occur in the ureters and renal pelvis. It begins in the urothelial cells lining these organs and can form tumors. The disease progresses by invading the bladder wall and potentially spreading to nearby tissues and lymph nodes. In advanced stages, it can metastasize to distant organs. Symptoms often include blood in the urine, frequent urination, and pelvic pain.

Ovarian Cancer – Ovarian cancer originates in the ovaries, often starting in the epithelial cells on the surface of the ovary. It progresses by forming tumors that can invade nearby tissues and organs, such as the fallopian tubes and uterus. As the disease advances, it can spread to the abdominal cavity and distant organs. Symptoms may include abdominal bloating, pelvic pain, and changes in bowel habits.

Cervical Cancer – Cervical cancer begins in the cells lining the cervix, the lower part of the uterus. It often starts with precancerous changes that can develop into cancer over time. The disease progresses by invading deeper tissues of the cervix and can spread to nearby lymph nodes. In advanced stages, it may metastasize to distant organs. Symptoms often include abnormal vaginal bleeding, pelvic pain, and pain during intercourse.

Biliary Tract Cancer – Biliary tract cancer, also known as cholangiocarcinoma, originates in the bile ducts. It begins with abnormal cell growth in these ducts, forming a tumor. The disease progresses by invading nearby tissues and can spread to lymph nodes and distant organs. Symptoms often include jaundice, abdominal pain, and weight loss as the disease advances.

HER2-Low Breast Cancer – HER2-low breast cancer is a subtype of breast cancer characterized by low levels of the HER2 protein on cancer cells. It begins in the breast tissue and can form a tumor. The disease progresses by invading nearby tissues and can spread to lymph nodes and distant organs. Symptoms may include a lump in the breast, changes in breast shape, and skin changes over the breast.

HER2 Immunohistochemistry 0 Breast Cancer – This subtype of breast cancer is characterized by the absence of HER2 protein expression on cancer cells. It begins in the breast tissue and can form a tumor. The disease progresses by invading nearby tissues and can spread to lymph nodes and distant organs. Symptoms may include a breast lump, changes in breast size or shape, and skin changes over the breast.

Cutaneous Melanoma – Cutaneous melanoma is a type of skin cancer that originates in the melanocytes, the cells responsible for skin pigment. It often begins as a mole that changes in size, shape, or color. The disease progresses by invading deeper layers of the skin and can spread to nearby lymph nodes. In advanced stages, it may metastasize to distant organs. Symptoms often include a new or changing mole, with irregular borders and multiple colors.