This study focuses on people who carry antibiotic-resistant bacteria called VRE (Vancomycin-Resistant Enterococci) and ESBL (Extended-Spectrum Beta-Lactamase) producing bacteria in their digestive system. These bacteria are resistant to common antibiotics, which means they are harder to treat if they cause an infection. The study aims to understand how antibiotic treatment affects these bacteria and other normal bacteria living in the gut.
The study will use two different antibiotics: ciprofloxacin and vancomycin. These medications will be given as tablets that participants take by mouth. The treatment will last for 5 days, during which participants will receive specific doses of the antibiotics. Ciprofloxacin may be given up to 1000 mg per day, while vancomycin may be given up to 500 mg per day.
During the study, researchers will collect stool samples to check for the presence of resistant bacteria and examine changes in the gut bacteria population. This will help understand how antibiotic treatment influences both harmful resistant bacteria and beneficial bacteria that normally live in the digestive system. The study will track these changes over time to see how long it takes for the gut bacteria to return to their normal state after antibiotic treatment.
Sweden 
