This clinical trial studies treatments for Acute Myeloid Leukemia (AML), high-risk Myelodysplastic Syndrome (MDS), and Myeloid Sarcoma in children under 18 years of age. The study tests different combinations of cancer medicines including Gemtuzumab Ozogamicin, Cytarabine, Mitoxantrone, Fludarabine, Busulfan, and Cyclophosphamide. These medications are given through an intravenous line (IV) directly into the bloodstream.
The main purpose of this study is to find the best treatment combination and dosing for children with these blood cancers. The study will compare different chemotherapy combinations and evaluate how well they work in treating the disease. It will also test different ways of preparing patients for stem cell transplantation, a procedure that replaces damaged bone marrow with healthy cells.
The study will track how patients respond to treatment by monitoring their blood and bone marrow. Researchers will look at how long patients stay free of disease, how well they tolerate the treatments, and any side effects that may occur. The study will continue to follow patients for up to 10 years to understand the long-term effects of these treatments.



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