This clinical trial is focused on studying the healing process of a specific condition known as perianal Crohn’s fistula, which is a complication of Crohn’s disease. Crohn’s disease is a long-term condition that causes inflammation of the digestive tract, and a fistula is an abnormal connection that can form between the intestine and the skin near the anus. The study will use a special imaging technique called FAPi-PET to observe the healing of these fistulas. The imaging involves a substance called Gallium (68Ga) Chloride, which is a type of radiopharmaceutical solution used to help visualize certain patterns in the body.

The purpose of the study is to see how well the 68Ga-FAPi-46 PET-CT scan can show and measure the activity of fibroblasts, which are cells involved in the healing process, during the early stages of healing in perianal Crohn’s fistulas. Participants in the study will undergo imaging at the start and at different times during the study to track changes. The study will help researchers understand how the healing process can be monitored using this imaging technique.

Throughout the study, the researchers will collect visual and quantitative data from the imaging to assess how the fistulas are healing over time. This information will be compared with other clinical assessments to provide a comprehensive view of the healing process. The study aims to improve understanding of how to monitor and potentially enhance the treatment of perianal Crohn’s fistulas using advanced imaging methods.