This study focuses on two rare heart conditions: Andersen-Tawil syndrome and Multifocal Ectopic Purkinje-related Premature Contractions. These conditions cause irregular heartbeats that originate from specific areas of the heart. The study aims to find the most effective treatment for controlling abnormal heart rhythms in patients with these conditions.
The study will test several medications including flecainide, which will be used alone or in combination with other heart medications. These additional medications include beta-blockers (bisoprolol, metoprolol, nebivolol, propranolol, atenolol) and calcium channel blockers like verapamil. For patients with Multifocal Ectopic Purkinje-related Premature Contractions, the medication quinidine will also be tested.
During the study, participants will take different combinations of these medications for specific periods. The medications will be given as oral tablets, and the treatment will continue for several weeks to determine which combination works best for each individual patient in controlling their irregular heart rhythms.



The Netherlands