This study focuses on treating systemic infections in critically ill children using three different antibiotics: amoxicillin-clavulanic acid, piperacillin-tazobactam, and meropenem. These medications are given through an intravenous line directly into the bloodstream to fight serious infections throughout the body.
The purpose of this research is to examine how well these antibiotics work when their dosing is guided by a special calculation method in critically ill children. The study will use precise measurements to determine if the right amount of medicine is reaching the infection. Each participant will receive one of the three antibiotics for up to 8 weeks of treatment.
During the study, doctors will monitor how the antibiotics work in the body by taking blood samples at different times. This helps ensure that enough medicine is present in the body to fight the infection effectively. The treatment approach being studied aims to provide more accurate dosing of these important medications for young patients who are seriously ill.



Belgium