This clinical trial is focused on studying the prevention of a condition known as postoperative pancreatic fistulas, which can occur after surgery on the pancreas. The pancreas is an organ in the body that helps with digestion and blood sugar regulation. A pancreatic fistula is a complication where digestive juices leak from the pancreas after surgery. The treatment being tested in this study is an injection of Botulinum toxin (BOTOX®), a substance that is commonly known for its use in cosmetic procedures but is also used in various medical treatments.

The purpose of this study is to explore whether injecting BOTOX® into a specific muscle called the sphincter of Oddi, which controls the flow of digestive juices, can safely and effectively prevent these fistulas from forming after a type of surgery called a distal pancreatectomy. This surgery involves removing part of the pancreas. The study will involve a series of steps where participants will receive the BOTOX® injection before their surgery, and researchers will monitor them to see if the treatment helps reduce the occurrence of pancreatic fistulas.

Participants in the study will undergo the BOTOX® injection before their scheduled surgery, and their recovery will be closely observed to assess the safety and feasibility of this approach. The study aims to determine if this method can be completed successfully in most patients and to evaluate its impact on reducing the risk of developing pancreatic fistulas after surgery. The findings from this study could potentially lead to improved outcomes for patients undergoing pancreatic surgery in the future.