This clinical trial is focused on studying a type of cancer called Mantle Cell Lymphoma, which is a rare form of non-Hodgkin’s lymphoma. The study is investigating the effectiveness of a treatment combination that includes the drugs Bendamustine, Rituximab, and Acalabrutinib (also known by its code name ACP-196). The purpose of the study is to evaluate how well this combination works compared to Bendamustine and Rituximab alone, with or without a placebo.
Participants in the study will receive treatment over a period of time, during which they will be given the medications either through an intravenous method, which means the drugs are delivered directly into a vein, or orally, which means they are taken by mouth in the form of capsules. The study is designed to be double-blind, meaning neither the participants nor the researchers know who is receiving the actual medication or the placebo, to ensure unbiased results.
The trial aims to assess the progression-free survival of patients, which refers to the length of time during and after treatment that a patient lives with the disease without it getting worse. This assessment will be done according to specific guidelines for non-Hodgkin’s lymphoma. The study will help determine if adding Acalabrutinib to the treatment regimen provides any additional benefit to patients with previously untreated Mantle Cell Lymphoma.
Belgium 
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Italy 
Poland 
Spain 