This clinical trial is focused on studying the treatment of Benign Prostate Hyperplasia (BPH), a condition where the prostate gland is enlarged, causing urinary problems. The study will explore the use of antibiotics before undergoing endoscopic surgery for BPH. The antibiotics being studied include Fosfomycin Calcium and a combination of Bromhexine Hydrochloride, Sulfamethoxazole, and Trimethoprim. These medications are commonly used to treat infections and will be compared to a placebo to see if they help reduce the risk of urinary tract infections after surgery.

The purpose of the study is to determine if not using antibiotics before surgery is just as effective as using them in preventing urinary tract infections within one month after the procedure. Participants will be randomly assigned to receive either the antibiotics or a placebo. The study will monitor the occurrence of urinary infections, characterized by symptoms like burning during urination, fever, and urgency, along with the presence of bacteria in the urine.

Throughout the study, researchers will also look at other factors, such as the number of surgeries canceled, the types of bacteria involved, and the costs associated with antibiotic treatment. The study aims to provide insights into whether the experimental approach is both clinically and economically comparable to the standard treatment. This research could potentially influence future prescribing practices for patients undergoing surgery for BPH.