This study focuses on Alzheimer’s Disease, a progressive brain disorder that affects memory and thinking skills. The research aims to examine specific protein deposits called tau aggregates in the brain using a special imaging substance called [18F]RO6958948. This substance helps to create detailed pictures of these protein deposits using a special type of scan called PET (Positron Emission Tomography).

During the study, participants will receive the imaging substance [18F]RO6958948 through an injection into a vein. The maximum amount given will be 370 MBq (a measure of radioactivity) as a single dose. The substance allows researchers to see the buildup of tau proteins in the brain, which is important in understanding how Alzheimer’s Disease develops and progresses.

The research will look at how these protein deposits relate to other brain changes that occur in Alzheimer’s Disease. Participants will undergo brain imaging both at a single point in time and over a longer period to track any changes. The study includes people who have previously participated in related research programs at the research center and will continue for several years to monitor changes in the brain over time.