This study focuses on patients with acute heart failure who have excess fluid in their body and may not respond well to standard water pill treatments. The research aims to find the most effective treatment strategy using two different medications: metolazone tablets and acetazolamide injection. These medications help remove excess fluid from the body.
The study will compare these medications with inactive treatments (placebo) that look identical to the real medicines. Some patients will receive metolazone tablets while others will get inactive tablets. Similarly, some patients will receive acetazolamide injections while others will get saline injections. The treatment period lasts for 4 days during the hospital stay.
The medications being tested are types of water pills (diuretics) that work differently from standard heart failure treatments. Metolazone is taken by mouth and helps the kidneys remove more water and salt from the body. Acetazolamide is given through an injection and works by reducing fluid buildup in the body through a different mechanism.



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