Diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS) – This is a type of non-Hodgkin lymphoma characterized by large B-cells that grow rapidly. It typically starts in lymph nodes but can also affect other organs. The disease progresses quickly, with symptoms such as swollen lymph nodes, fever, and weight loss. It can spread to other parts of the body, including the bone marrow and central nervous system.
Primary cutaneous diffuse large B-cell lymphoma, leg type – This lymphoma primarily affects the skin, particularly on the legs. It presents as rapidly growing tumors or nodules on the skin. The disease progresses with the potential to spread to other areas of the skin and sometimes to internal organs. It is characterized by large B-cells in the skin tissue.
Intravascular large B-cell lymphoma – This rare lymphoma involves the growth of large B-cells within the blood vessels. It often affects the skin and central nervous system, leading to symptoms like skin lesions and neurological issues. The disease progresses as these cells obstruct blood flow, causing organ dysfunction. It can be challenging to diagnose due to its non-specific symptoms.
Epstein-Barr virus-positive diffuse large B-cell lymphoma not otherwise specified (EBV+ DLBCL NOS) – This lymphoma is associated with the Epstein-Barr virus and involves large B-cells. It typically affects older adults and can present with symptoms like swollen lymph nodes and fever. The disease progresses with the potential to involve multiple organs. It is characterized by the presence of EBV in the tumor cells.
Human herpesvirus 8-positive diffuse large B-cell lymphoma not otherwise specified (HHV8+ DLBCL NOS) – This lymphoma is linked to human herpesvirus 8 and involves large B-cells. It often occurs in individuals with compromised immune systems. The disease progresses with symptoms such as lymph node enlargement and systemic involvement. It is characterized by the presence of HHV8 in the tumor cells.
Primary mediastinal (thymic) large B-cell lymphoma – This type of lymphoma originates in the thymus, located in the mediastinum. It presents with symptoms like chest pain, cough, and breathing difficulties. The disease progresses as the tumor grows and may spread to nearby structures. It is characterized by large B-cells in the thymic tissue.
B-cell lymphoma, with intermediate features between diffuse large B-cell lymphoma and classical Hodgkin lymphoma – This lymphoma exhibits characteristics of both DLBCL and Hodgkin lymphoma. It presents with symptoms like swollen lymph nodes and fever. The disease progresses with the potential to involve multiple lymph node regions. It is characterized by a mix of cell types found in both DLBCL and Hodgkin lymphoma.
Follicular lymphoma grade 3B – This is a type of non-Hodgkin lymphoma with large B-cells arranged in follicular patterns. It presents with symptoms like painless lymph node swelling. The disease progresses with the potential to transform into a more aggressive form. It is characterized by a high number of large cells in the lymph nodes.
High-grade B-cell lymphoma not otherwise specified (NOS) – This aggressive lymphoma involves large B-cells and presents with rapidly growing lymph nodes. It can affect various organs and tissues. The disease progresses quickly, often requiring prompt medical attention. It is characterized by high-grade features in the tumor cells.
High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements – This lymphoma is marked by genetic changes involving MYC, BCL2, and/or BCL6 genes. It presents with aggressive growth and symptoms like swollen lymph nodes and fever. The disease progresses rapidly, often involving multiple organs. It is characterized by specific genetic rearrangements in the tumor cells.
T-cell/histiocyte-rich large B-cell lymphoma – This rare lymphoma involves large B-cells with a significant number of T-cells and histiocytes. It presents with symptoms like lymph node enlargement and systemic symptoms. The disease progresses with the potential to affect various organs. It is characterized by a unique cellular composition in the tumor.
Diffuse large B-cell lymphoma associated with chronic inflammation – This lymphoma occurs in areas of long-standing inflammation. It presents with symptoms like swelling and pain in the affected area. The disease progresses as the lymphoma cells grow in the inflamed tissue. It is characterized by the presence of large B-cells in chronically inflamed areas.
Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+ large B-cell lymphoma) – This rare lymphoma involves large B-cells with ALK gene rearrangements. It presents with symptoms like swollen lymph nodes and systemic symptoms. The disease progresses with the potential to spread to other organs. It is characterized by the presence of ALK protein in the tumor cells.
Large B-cell lymphoma with IRF4 rearrangement – This lymphoma involves large B-cells with genetic changes in the IRF4 gene. It presents with symptoms like lymph node enlargement and systemic symptoms. The disease progresses with the potential to affect various organs. It is characterized by specific genetic rearrangements in the tumor cells.
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