This study focuses on Dominantly Inherited Alzheimer’s Disease (DIAD), a rare genetic form of Alzheimer’s Disease that occurs early in life due to specific genetic mutations. The study will test a new medication called Remternetug (also known as LY3372993) against placebo in people who carry these genetic mutations but have not yet developed symptoms. Another substance called Pittsburgh compound B will be used for brain imaging during the study.
The main purpose is to determine if the treatment can prevent or slow down the buildup of harmful proteins in the brain before memory and thinking problems begin. The study is divided into two stages and will use various methods to measure changes in the brain, including special brain scans and tests of spinal fluid.
Participants will receive either Remternetug as an injection under the skin or a matching placebo for up to 108 weeks. Throughout the study, participants will undergo various tests to monitor their brain health and check for any changes. The study will also track the safety of the treatment by monitoring for side effects and performing regular health checks.



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