Probenecid is a medication that is being studied to help control cluster seizures in patients with epilepsy. It is being tested specifically during the period when patients are reducing their regular anti-seizure medications before undergoing video-EEG monitoring. This medication may help prevent or stop multiple seizures that occur close together (cluster seizures).

Anti-Seizure Medications (ASMs) are the regular medications that patients with epilepsy take to control their seizures. In this study, these medications are temporarily reduced, which is a standard procedure before certain types of brain monitoring, but this reduction can sometimes trigger seizures.

Focal Epilepsy – A type of epilepsy where seizures begin in a specific area of the brain, affecting one particular region or side. During these seizures, a person may experience various symptoms depending on which part of the brain is involved, such as unusual sensations, involuntary movements, or changes in awareness. The seizures can occur in clusters, meaning multiple seizures happen within a short period. In focal epilepsy, electrical disturbances remain localized to one area of the brain, though sometimes they can spread to other regions. The condition can affect people of any age and may be caused by various factors including brain injury, infections, or structural abnormalities.