This study focuses on patients with Atherosclerotic Cardiovascular Disease who have previously experienced a myocardial infarction (heart attack) and show signs of inflammation in their coronary arteries. The study will test a medication called orticumab, which is given as an injection, to determine its effects on reducing inflammation in the heart’s blood vessels.

The research will examine how well orticumab works compared to placebo in treating coronary artery inflammation. The inflammation will be measured using a special technique called Fat Attenuation Index score, which is determined through Coronary Computed Tomography Angiography (a detailed heart imaging scan). The study will look at three main blood vessels of the heart: the right coronary artery, left anterior descending artery, and left circumflex artery.

Participants in this study will receive treatment for 6 months. During this time, they will undergo various health checks, including blood tests, physical examinations, and heart scans. The study will monitor both the effectiveness of the treatment and any side effects that may occur. Throughout the study, participants will continue taking their regular heart medications as prescribed by their doctors.