This clinical trial focuses on preventing Respiratory Syncytial Virus (RSV) infections, bronchiolitis, and respiratory tract infections in infants. The study examines two different prevention approaches using Beyfortus (nirsevimab) and Abrysvo, which are medications given as injections into the muscle. RSV is a common virus that can cause serious breathing problems in babies, especially during their first year of life.
The purpose of this research is to determine whether giving both an RSV vaccine to pregnant mothers and nirsevimab to their babies at 4 months of age works better than giving only nirsevimab to infants during RSV season. The study will track how well these approaches protect babies from developing RSV-related breathing problems during their first year of life.
Participants will be divided into two groups. In one group, pregnant mothers will receive the Abrysvo vaccine between weeks 32 and 36 of pregnancy, and their babies will later receive Beyfortus at 4 months of age. In the other group, babies will receive only Beyfortus during the RSV season. The babies’ health will be monitored throughout their first year of life to check for any breathing problems or infections.



France