This study focuses on people with Type 2 Diabetes who are currently using either semaglutide or tirzepatide injections but have not achieved their desired blood sugar control. The study will test a new medication called LY3457263 (also known as nisotirotide) to see if it can help lower blood sugar levels when added to current treatment.
The study medication or placebo will be given as an injection under the skin (subcutaneous injection) once per week. The study will compare how well LY3457263 works compared to placebo in controlling blood sugar levels, specifically by measuring HbA1c (a measure of average blood sugar over the past 2-3 months).
Participants will receive either the study medication or placebo for 24 weeks. During this time, they will continue their regular diabetes medication (semaglutide or tirzepatide). The study will involve people who are overweight or have obesity and whose body weight has been stable for at least three months.



Germany
Poland