This clinical trial focuses on treating Multiple Myeloma that has returned or stopped responding to previous treatments. The study tests a combination of three medications: isatuximab (given through an intravenous infusion), evorpacept (given as an injection), and dexamethasone (taken as tablets). Multiple Myeloma is a type of blood cancer that affects plasma cells, which are cells in the bone marrow that help fight infections.
The main purpose of this study is to find the best dose of these medications when used together and to see how well they work in treating Multiple Myeloma that has come back after at least two previous treatments. The study is divided into two parts: the first part focuses on finding the right dose combination, while the second part looks at how effective this treatment is at controlling the cancer.
During the study, participants will receive the combination of medications and will be monitored regularly to check how their cancer responds to the treatment. The medications work in different ways to fight cancer cells: isatuximab targets specific proteins on cancer cells, evorpacept helps the immune system fight cancer cells, and dexamethasone helps reduce inflammation and supports the other medications’ effects.



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