This study focuses on patients with relapsed or refractory multiple myeloma, a type of blood cancer that returns after treatment or does not respond to previous treatments. The study will test a combination of three medications: isatuximab, belantamab mafodotin, and dexamethasone. Isatuximab and belantamab mafodotin are specialized drugs that target specific proteins on cancer cells, while dexamethasone is a steroid medication that helps fight cancer cells.
The purpose of this research is to find the most effective and safe dose of these medications when used together in treating multiple myeloma that has returned or not responded to at least two previous treatments. The study is divided into two parts – the first part will determine the right dose of the medications, and the second part will test how well the combination works at the chosen dose.
During the study, participants will receive the medications through different routes – isatuximab and belantamab mafodotin will be given through an intravenous infusion (directly into a vein), while dexamethasone will be taken as tablets by mouth. The study will monitor how participants respond to the treatment and track any side effects that may occur.



Greece
Italy
Norway