This clinical study focuses on people with primary Raynaud’s phenomenon, a condition where blood vessels in the fingers and toes narrow excessively in response to cold temperatures or stress, causing affected areas to turn white and blue and feel numb or painful. The study will test a medication called sodium thiosulfate, given through intravenous administration (directly into a vein) as a solution for infusion.
The purpose of this research is to determine how different doses of sodium thiosulfate affect blood vessel widening in people with Raynaud’s phenomenon. During the study, participants will receive the medication through an infusion into their veins. The maximum daily dose will be 25 grams, and the treatment period will last for one day.
The study will measure how well blood flows through the small blood vessels in participants’ hands using special imaging techniques. Researchers will also monitor the safety of the treatment by checking blood pressure, heart activity, and looking for any unwanted effects. Blood samples will be collected to understand how the medication moves through the body and affects various biological processes.
The Netherlands 