This study focuses on people with Chronic Obstructive Pulmonary Disease who have increased lung volume. The research will test a combination inhaler called Trixeo Aerosphere, which contains three medicines: budesonide, glycopyrronium bromide, and formoterol fumarate dihydrate. These medications work together to help open the airways and reduce inflammation in the lungs.
The purpose of this research is to understand how this inhaled medication affects heart and lung function compared to placebo. The study will use special imaging techniques including magnetic resonance imaging to look at the heart’s size and function. It will also measure how much air remains in the lungs after breathing out using a technique called body plethysmography.
During the study, participants will receive both the medication and placebo at different times through an inhaler device called a metered dose inhaler. The treatment will be given twice daily. Neither the participants nor the doctors will know which treatment is being given at any particular time. This helps ensure that the results are not influenced by expectations about the treatment.
Germany 
