BOLD-100 is an investigational medication being studied in combination with other cancer treatments. It’s being tested as a new potential treatment for various types of advanced solid tumors.

FOLFOX is a combination chemotherapy treatment commonly used to treat various types of cancer. It consists of three medications: fluorouracil (5-FU), leucovorin, and oxaliplatin. This is a standard treatment that works by stopping or slowing the growth of cancer cells.

The trial combines these two treatments (BOLD-100 with FOLFOX) to study if they work better together in treating patients with advanced solid tumors than existing treatments alone.

Advanced Solid Gastrointestinal Tumors – A condition where abnormal cells form masses in various parts of the digestive system, including the stomach, intestines, and other digestive organs. These tumors have grown beyond their initial location and may have spread to nearby tissues.

Cholangiocarcinoma – A cancer that develops in the cells of the bile ducts, which are tubes that connect the liver to the small intestine. The disease causes the bile duct cells to grow abnormally, forming tumors that gradually block the bile ducts.

Colorectal Cancer – A disease that begins in either the colon or rectum, where cells in the intestinal lining begin to grow abnormally. The disease typically develops from small growths called polyps, which over time can become cancerous and grow into the wall of the colon or rectum.

Gastric Cancer – A disease that occurs when abnormal cells develop in the lining of the stomach. The condition typically develops slowly over many years, starting in the stomach’s inner lining and gradually growing deeper into the stomach walls.

Pancreatic Cancer – A condition where abnormal cells form in the tissues of the pancreas, an organ located behind the stomach. The disease begins when cells in the pancreas start to grow uncontrollably, forming masses that disrupt normal pancreatic function.