BMS-986466 is an experimental drug being tested to see if it can help treat certain types of cancer. In this study, it is being used to see if it can work together with other cancer treatments to stop or slow down the growth of tumors. The goal is to find out if this drug is safe for patients and to determine the best dose to use in future studies.

Adagrasib is a medication that targets a specific mutation in cancer cells known as KRAS G12C. This mutation is found in some types of advanced cancers, such as lung and colorectal cancer. Adagrasib works by blocking the signals that tell cancer cells to grow and divide, which may help to slow down or stop the progression of the disease.

Cetuximab is a type of therapy known as a monoclonal antibody. It is used to treat certain types of cancer by targeting a protein on the surface of cancer cells. This protein is involved in the growth and spread of cancer cells. By blocking this protein, cetuximab can help to slow down or stop the growth of tumors. In this study, it is being used in combination with other treatments to see if it can improve their effectiveness against cancer.

Non-Small Cell Lung Cancer (NSCLC) – Non-Small Cell Lung Cancer is a type of lung cancer that includes several subtypes such as adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. It typically begins in the tissues of the lungs and can spread to other parts of the body. The disease progresses as cancer cells grow uncontrollably, forming tumors that can interfere with normal lung function. Over time, these tumors may invade nearby tissues and organs. As the disease advances, it can metastasize to distant parts of the body, affecting overall health and organ function. The progression rate can vary depending on the subtype and individual patient factors.

Colorectal Cancer (CRC) – Colorectal Cancer is a type of cancer that starts in the colon or rectum, parts of the large intestine. It often begins as small, benign clumps of cells called polyps, which can develop into cancer over time. As the disease progresses, cancer cells can grow into the wall of the colon or rectum and spread to nearby lymph nodes and other organs. The progression involves the growth of tumors that can obstruct the bowel and cause various symptoms. Advanced stages may involve metastasis to distant organs such as the liver or lungs. The rate of progression can vary based on genetic factors and the cancer’s location within the colon or rectum.

Pancreatic Ductal Adenocarcinoma (PDAC) – Pancreatic Ductal Adenocarcinoma is the most common type of pancreatic cancer, originating in the ducts of the pancreas. It typically progresses rapidly, with cancer cells forming tumors that can block the bile duct and cause jaundice. As the disease advances, it can invade nearby organs such as the stomach and intestines. The cancer may also spread to distant organs, including the liver and lungs. Tumor growth can lead to symptoms like abdominal pain and weight loss. The progression is often aggressive, impacting the function of the pancreas and other affected organs.

Biliary Tract Cancer (BTC) – Biliary Tract Cancer refers to cancers that occur in the bile ducts, gallbladder, or ampulla of Vater. It often begins in the cells lining the bile ducts and can obstruct the flow of bile, leading to jaundice. As the disease progresses, tumors can grow and invade nearby tissues and organs, such as the liver and pancreas. The cancer may spread to distant parts of the body, affecting overall health. Symptoms can include abdominal pain, weight loss, and changes in liver function. The progression can vary depending on the cancer’s location and the patient’s overall health.