This study focuses on patients with Multiple Sclerosis, specifically the relapsing-remitting form of the disease. The study compares different treatment approaches: autologous hematopoietic stem cell transplantation (a procedure using the patient’s own stem cells) versus three alternative medications – alemtuzumab, cladribine, or ocrelizumab. The purpose is to evaluate which treatment option is more effective and safe for patients with aggressive forms of relapsing-remitting Multiple Sclerosis.
Before the main treatment begins, patients receiving stem cell transplantation will be given cyclophosphamide and antithymocyte immunoglobulin as preparation medications. The medications used in the comparison group are given differently: Mavenclad (cladribine) is taken as tablets, Lemtrada (alemtuzumab) and Ocrevus (ocrelizumab) are given through infusion into a vein.
The study will monitor patients for five years to track their disease activity. This includes checking for new symptoms, performing brain scans to look for changes, and evaluating how well patients can perform daily activities. The study will also look at quality of life and ability to work.



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