This study involves patients with obesity, specifically those with severe obesity where the body mass index is 40 or higher. The study will use rocuronium bromide, which is a medication that temporarily relaxes muscles to help place a breathing tube during surgery. The study will also use propofol, which is a medication used to put patients to sleep during surgery, and sodium chloride, which is a salt solution used to flush the medication through the vein. The purpose of the study is to compare how well the breathing tube can be placed when the dose of rocuronium is calculated based on ideal body weight compared to when it is calculated based on actual body weight in patients with severe obesity.
During the study, patients will be prepared for surgery that requires a breathing tube. They will receive oxygen before the procedure begins. Then they will be given medications to put them to sleep and relax their muscles. The muscle relaxing medication will be given in a dose that is calculated either based on what the patient should ideally weigh or based on what they actually weigh. The doctor will then place the breathing tube and evaluate how easy or difficult it was to do this. The time it takes to place the tube will be measured, and the level of muscle relaxation will be checked. The oxygen levels in the blood will be monitored throughout the procedure.
The study will look at whether excellent conditions for placing the breathing tube are achieved with either dosing method. It will also examine how many patients have acceptable conditions for tube placement, how long it takes to successfully place the tube, and whether any extra techniques are needed to get a better view of the airway. The study will record oxygen levels at different times during the procedure and track any problems that occur, such as drops in oxygen levels or changes in blood pressure. The study is expected to begin enrolling patients in October 2025 and continue until the end of 2028.



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