Esketamine (oral form) is a medication used to treat severe depression that hasn’t responded to other treatments. It works by targeting brain receptors involved in mood regulation. This medication is a modified form of ketamine and is taken by mouth to help improve depressive symptoms in people who haven’t found relief with standard antidepressants.

Electroconvulsive Therapy (ECT) is a medical procedure that involves passing small electrical currents through the brain while the patient is under anesthesia. This treatment causes brief changes in brain chemistry that can quickly reverse symptoms of certain mental health conditions, particularly severe depression. It’s typically used when other treatments haven’t been successful.

Non-psychotic Therapy Resistant Unipolar Depression – A severe form of major depressive disorder that has not responded to at least two different antidepressant treatments. It is characterized by persistent low mood, loss of interest in activities, changes in sleep and appetite, and reduced energy levels that continue despite standard treatments. The condition affects daily functioning and occurs without psychotic symptoms such as hallucinations or delusions. This form of depression shows minimal or no improvement with conventional antidepressant medications over extended periods.