Inclisiran is a medication used to lower LDL cholesterol levels in the blood. It works by targeting a specific protein in the liver, which helps reduce the amount of cholesterol produced by the body. This medication is being tested to see if it is more effective than other treatments in lowering cholesterol for people with cardiovascular disease.

Bempedoic Acid is another medication aimed at reducing LDL cholesterol levels. It works by inhibiting an enzyme involved in cholesterol production in the liver. This trial is comparing its effectiveness to Inclisiran in managing cholesterol levels in patients with cardiovascular conditions.

Statins are a group of medications commonly used to lower cholesterol levels. They work by blocking a substance your body needs to make cholesterol, which can help prevent heart disease and stroke. In this trial, participants are receiving the highest dose they can tolerate as part of their standard care.

Ezetimibe is a medication that helps lower cholesterol levels by reducing the amount of cholesterol absorbed by the intestines. It is often used in combination with statins to enhance cholesterol-lowering effects. In this study, it may be used alongside other treatments to help manage cholesterol levels.

Hypercholesterolemia – This condition is characterized by high levels of cholesterol in the blood, particularly low-density lipoprotein cholesterol (LDL-C), which is often referred to as “bad” cholesterol. Over time, the excess cholesterol can build up in the walls of arteries, leading to atherosclerosis, which is the narrowing and hardening of the arteries. This process can reduce or block blood flow, potentially leading to complications such as heart disease or stroke. Hypercholesterolemia can be influenced by genetic factors, diet, lifestyle, and other health conditions. It often progresses silently without symptoms until significant arterial damage occurs. Regular monitoring of cholesterol levels is important to manage and understand the progression of this condition.