This clinical trial studies the treatment of periprosthetic joint infection, which is an infection occurring around artificial joints in the knee, hip, or shoulder. The study compares two treatment approaches: a new antibiotic called dalbavancin versus standard antibiotic therapy. Standard antibiotics that may be used include amoxicillin, linezolid, flucloxacillin, gentamicin, vancomycin, and several others.
The main purpose of the study is to compare the costs and effectiveness of these treatments while also looking at how they affect patients’ quality of life. The study will measure antibiotic levels in bone and tissue, track physical activity during treatment, and examine how the medications affect bacteria in the digestive system.
Treatment will last between 6 and 12 weeks, depending on the specific case. Patients will be monitored for up to one year to check for any complications or return of infection. During the study, participants will wear an activity tracker and complete questionnaires about their health and quality of life. Some participants will also provide tissue samples for laboratory analysis.
Denmark 
