This study focuses on treating patients with Multiple Myeloma that has returned or not responded to previous treatment. The research compares two different treatment combinations. The first combination includes belantamab mafodotin, bortezomib, and dexamethasone. The second combination uses daratumumab instead of belantamab mafodotin, along with bortezomib and dexamethasone.
The medications will be given in different ways – some as tablets taken by mouth, while others will be given through an intravenous line (directly into a vein). Dexamethasone comes as tablets and can also be given through an intravenous line. Bortezomib and daratumumab are given through an intravenous line, while belantamab mafodotin is given as a powder that is mixed into a solution for intravenous use.
The main purpose of this study is to determine if the treatment combination with belantamab mafodotin works better than the combination with daratumumab in preventing the cancer from getting worse. The study will measure how long participants live without their disease getting worse, along with tracking side effects and other health outcomes.



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