This clinical trial is focused on studying the effectiveness and safety of two medications, Atogepant and Topiramate, for the preventive treatment of migraine. Migraines are severe headaches that can cause intense throbbing or pulsing sensations, often accompanied by nausea, vomiting, and sensitivity to light and sound. The purpose of the study is to compare how well these medications work and how safe they are for people who need to prevent migraines.

Participants in the study will be randomly assigned to receive either Atogepant, Topiramate, or a placebo. A placebo is a substance with no active medication, used to compare the effects of the actual drugs. The study will last for several weeks, during which participants will take the assigned medication and report any side effects or changes in their migraine symptoms. The study aims to find out if Atogepant is as effective and safe as Topiramate, which is already used for migraine prevention.

Throughout the study, participants will have regular check-ups to monitor their health and any changes in their migraine patterns. The study will also include an open-label extension, where all participants may have the opportunity to receive Atogepant to further assess its long-term safety and effectiveness. This trial is an important step in understanding how these medications can help people who suffer from migraines and improve their quality of life.