This clinical trial is focused on studying the effectiveness and safety of treatments for patients with neuroendocrine tumors of the lung and thymus. These are a type of cancer that can occur in the hormone-producing cells of the lung and thymus. The study will compare two treatments: 177Lu-Edotreotide, a solution for injection or infusion, and Afinitor (everolimus), which is taken as a tablet. The purpose of the study is to see how well these treatments work in stopping the cancer from getting worse and to understand their safety and how they affect patients’ quality of life.
Participants in the study will receive either 177Lu-Edotreotide or Afinitor. 177Lu-Edotreotide is given through an intravenous infusion, which means it is delivered directly into the bloodstream. Afinitor is taken orally as a tablet. The study will also include a group of participants who will receive a placebo, which is a substance with no active medication, to help compare the effects of the treatments. The study will last for a period of time, during which participants will be monitored regularly to assess the progression of their disease and any side effects they may experience.
The main goal of the study is to determine how long the treatments can prevent the cancer from progressing, which is known as progression-free survival. This will be measured from the time participants start the study until their disease shows signs of getting worse or they pass away. The study will also collect information on how the treatments impact the participants’ daily lives and overall well-being. This information will help doctors understand which treatment might be more beneficial for patients with neuroendocrine tumors of the lung and thymus.



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