Phase IIb Randomized, Double‑Blind Study of GIA632 in Adults with Nonsegmental Vitiligo

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What is this study about?

Non‑segmental vitiligo is a skin condition in which the immune system gradually removes pigment from large areas of the skin, often affecting the face and visible parts of the body. The study is testing a new medication called GIA632, which is given as a small injection under the skin, and comparing it with a harmless substance known as placebo to see if it can help restore color to the affected areas.

The main goal of the trial is to find the dose of GIA632 that works best for increasing skin color in people with this type of vitiligo. Participants will receive a series of injections over several months, with regular check‑ins to monitor any changes in the appearance of the skin and to watch for possible side effects. The study also uses a simple scoring system called the facial Vitiligo Area Scoring Index to measure how much the facial skin has repigmented, helping researchers understand whether the treatment is effective and safe.

Who Can Join the Study?

  • Provide written permission (called informed consent) after the study is explained to you.
  • Be 18 years of age or older at the time of screening, no matter whether you were assigned male or female at birth.
  • Have a doctor confirm that you have non‑segmental vitiligo, a form of vitiligo that causes many depigmented patches across different parts of the skin.
  • Show that the vitiligo affects at least 0.5% of the skin on your face and have a facial score (the F‑VASI score) of 0.5 or higher, or that it covers at least 3% of the skin on other parts of your body (including hands and feet) and have a total body score (the T‑VASI score) between 3 and 60. Body Surface Area (BSA) refers to the percentage of your skin that is affected.

Who Cannot Join the Study?

  • Unable or unwilling to follow the study steps and to complete the study questionnaires.
  • Having segmental or mixed vitiligo (a form that affects only one side or a limited area) or other skin problems that could affect the study results, such as hypopigmented mycosis fungoides (a type of skin lymphoma that causes lighter patches), genetic pigment disorders like piebaldism or Waardenburg syndrome (conditions that cause patches of missing pigment), or skin lightening caused by chemicals or medicines (chemical‑ or drug‑induced leukoderma).
  • Previous use of biologic medicines that directly target IL‑15 or its receptors (IL‑15 is a protein that helps control the immune system).
  • Having tried or completed a skin‑lightening treatment called depigmentation therapy for vitiligo (a procedure that intentionally removes remaining pigment from the skin).
  • Using any medication or treatment that the study lists as not allowed (prohibited medication & treatments).

Where you can join this trial?

Verified and Recommended Sites

No sites found in this category

Verified Sites

Site Name City Country Status
IRCCS Humanitas Research Hospital Rozzano Italy
Centre Hospitalier Universitaire De Bordeaux Bordeaux France
Centre Hospitalier Regional Et Universitaire De Brest Brest France
Oncopole Claudius Regaud Toulouse France
Medizinische Hochschule Hannover Hanover Germany

Other Sites

Site Name City Country Status
Centre Hospitalier Universitaire Rouen Rouen France
Universitaetsklinikum Tuebingen AöR Tuebingen Germany
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico Milan Italy
Universita’ Politecnica Delle Marche Ancona Italy
Universidade De Santiago De Compostela Santiago De Compostela Spain
Centre Hospitalier Universitaire De Nice Nice France
Universitaetsklinikum Schleswig-Holstein AöR Kiel Germany
Hopital Beaujon Clichy France
Hospital Universitario 12 De Octubre Madrid Spain
Universita’ Degli Studi Di Ferrara Ferrara Italy
Complexo Hospitalario Universitario De Pontevedra Pontevedra Spain
El Hospital Universitario De Gran Canaria Dr. Negrin Las Palmas De Gran Canaria Spain
Dermatologikum Hamburg GmbH Hamburg Germany
Klinikum Bielefeld gGmbH Bielefeld Germany
Courlancy Sante Reims France
Aobzuicxd Utx Amsterdam The Netherlands
Evscmzf Unydrthnxivf Mmawrlm Cenusxq Rxdnpaqth (zybkzky Mxg Rotterdam The Netherlands
Ujlxqgirgxfdofzjvkfcq Mjmhwagc Abx Munster Germany
Gtvbps Ujphlvyjee Fhquwvqbo Frankfurt Germany
Kbraugdp dhs Upneqbuvcoyz Mthkwdix Agz Munich Germany
Hhrukozy Da Lp Shads Cmta I Sbzl Pbr Barcelona Spain
Hgythtaj Ulkckqsnmqmly Dl Li Pznyspdf Madrid Spain
Tnicytxbfnm uoc Sjnqtgjnrlp Bcncnxyt Gsmh Bad Bentheim Germany

Want to learn more about this study or check if you can participate? Contact us.

Trial status

Country Status Recruitment Start
France France
Recruiting
01.07.2026
Germany Germany
Recruiting
01.07.2026
Italy Italy
Not yet recruiting
01.07.2026
Spain Spain
Not yet recruiting
01.07.2026
The Netherlands The Netherlands
Not yet recruiting
01.07.2026

Trial locations

GIA632
GIA632 is an experimental medicine being tested for people with non‑segmental vitiligo, a condition that causes loss of skin color in patches. In this study, participants receive GIA632 by a small injection under the skin. The goal is to see if the medicine can help the skin regain its normal color, especially on the face, by comparing changes in a skin‑pigment score after several weeks of treatment. The trial examines different amounts of the medicine to find the best dose that works safely and effectively.

Investigated diseases:

Nonsegmental vitiligo – Nonsegmental vitiligo is a chronic skin condition characterized by loss of pigment in patches that are not limited to a single dermatome. It typically begins with small lighter spots that gradually enlarge and can spread to other areas of the body over time. The distribution of depigmented patches may be symmetric and can affect the face, hands, and other exposed skin. The condition progresses at varying rates, with some individuals experiencing slow changes while others notice more rapid spread.

Trial ID:
2025-522301-37-00
Protocol code:
CGIA632B12201
Trial Phase:
Therapeutic exploratory (Phase II)

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