Multiple Ascending Dose Safety, Tolerability and Pharmacokinetics of MK-7602 in Healthy Volunteers for Malaria

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What is this study about?

Malaria is an illness caused by tiny parasites that are spread through mosquito bites and can lead to fever, chills, and flu‑like symptoms. The study drug MK-7602 is given as a hard capsule taken by mouth, and a matching placebo capsule that contains no active medicine is also used for comparison.

The main goal of the trial is to see whether multiple daily doses of the medication are safe and well tolerated in healthy volunteers and to gather early information on its pharmacokinetics, which means how the body absorbs, distributes, and removes the drug. Researchers will watch for any adverse event (side effect) and will measure the amount of drug in the blood, referred to as plasma, at several time points to understand how long the drug stays in the system, its half‑life, and how quickly it is cleared.

Participants will take the assigned capsule once each day for seven days. During this period, short clinic visits will be scheduled to collect blood samples and check for any side effects. After the final dose, additional blood draws will be done to complete the safety checks and the drug‑level measurements, after which participants will be monitored for a short follow‑up period.

Who Can Join the Study?

Who Cannot Join the Study?

Where you can join this trial?

Verified and Recommended Sites

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Verified Sites

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Other Sites

Site Name City Country Status
Universitair Ziekenhuis Gent Gent Belgium

Want to learn more about this study or check if you can participate? Contact us.

Trial status

Country Status Recruitment Start
Belgium Belgium
Not recruiting
16.05.2023

Trial locations

Trial ID:
2023-503738-36-00
Protocol code:
MK-7602-002
Trial Phase:
Human Pharmacology (Phase I) – Other

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