Long‑term immunity after MEASLES, COMBINATIONS WITH MUMPS AND RUBELLA, LIVE ATTENUATED vaccine given at 6 months in children

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What is this study about?

The study focuses on the viral illnesses measles, mumps and rubella, which can be prevented by a single injection called the MMR vaccine. This vaccine contains weakened (live attenuated) viruses that stimulate the body’s defense without causing the diseases. In the trial, infants receive either the vaccine or a placebo at six months of age, followed by the routine childhood dose at four years.

The purpose of the study is to compare the long‑term immune response after an early dose of the vaccine versus the placebo. Researchers will look at the level of protection by measuring specific proteins, known as neutralising antibodies, that can block the measles virus.

After the initial injection, children continue with the normal vaccination schedule. Several years later, a small blood sample is taken to assess how many protective antibodies are present, using a laboratory method that counts how well the blood can stop the virus from growing. This follow‑up helps determine whether giving the vaccine earlier influences lasting immunity.

1 enrollment

after providing informed consent, baseline information is recorded and a schedule of study visits is given to you.

2 early mmr vaccination (6 months)

you receive a single mmr vaccine dose. the vaccine is administered as a 0.5 ml intramuscular injection in the upper arm.

the injection contains live, weakened viruses that stimulate the immune system to protect against measles, mumps, and rubella.

after the injection you remain in the clinic for observation (usually 15–30 minutes) to monitor any immediate reactions.

3 routine mmr vaccination (4 years)

at age 4 years you receive the routine mmr vaccine dose, given as a single intramuscular injection according to the standard schedule.

the vaccine is the same type of live, weakened viruses as the early dose.

4 first follow‑up blood test (1 year after routine mmr)

approximately one year after the routine vaccination, you attend a clinic visit for a blood draw.

the sample is used to measure the level of antibodies (immune proteins) against measles, mumps, and rubella.

5 final follow‑up blood test (1–3 years after routine mmr)

between one and three years after the routine vaccination, you provide a second blood sample.

this test evaluates the long‑term persistence of immunity by measuring specific antibodies, especially measles neutralising antibodies.

Who Can Join the Study?

  • You must have participated in the original MMR vaccine trial.
  • You must be a healthy volunteer, meaning you do not have any serious illnesses that could affect the study results.
  • Both boys and girls (male and female) are allowed to join.
  • You must be within the age range set by the study for children.

Who Cannot Join the Study?

  • Having an immune deficiency (a weakened immune system) or being on medicines that suppress the immune system, such as high doses of corticosteroids.
  • Having a low platelet count (thrombocytopenia) or any disorder that affects blood clotting (coagulation disorder).
  • Having blood disorders (blood dyscrasias), leukaemia, any type of lymphoma, or other cancers that involve the blood‑forming (haematopoietic) or lymphatic systems.
  • Having received a blood or plasma transfusion, or an injection of human immune serum globulin, within the past three months.

Where you can join this trial?

Verified and Recommended Sites

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Verified Sites

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Other Sites

Site Name City Country Status
Rigshospitalet Copenhagen Denmark

Want to learn more about this study or check if you can participate? Contact us.

Trial status

Country Status Recruitment Start
Denmark Denmark
Not yet recruiting
01.05.2026

Trial locations

Measles, mumps and rubella vaccine (MMR)

This is a live‑attenuated vaccine given by injection into the muscle. It contains weakened forms of the measles, mumps, and rubella viruses. The purpose of the vaccine in the study is to protect children from these three infections and to allow researchers to see how well the immune system remembers the protection several years later. Children in the trial received this vaccine at 6 months of age, and the study later measured the level of antibodies they produced to see how long the protection lasts.

Investigated diseases:

Measles – Measles is a contagious viral infection that begins with fever, cough, runny nose, and red eyes. After a few days a red rash appears, starting on the face and spreading downward. The rash typically lasts about a week before fading. Symptoms usually develop 10‑14 days after exposure and then improve gradually.
Mumps – Mumps is a viral illness that primarily affects the salivary glands. It starts with fever, headache, and muscle aches, followed by swelling of one or both cheeks. The swelling can last several days and then slowly reduces. The illness usually resolves on its own within a week or two.
Rubella – Rubella, also known as German measles, is a mild viral infection. It begins with a low fever and a pink rash that starts on the face and spreads to the body. The rash typically lasts three to four days. Symptoms appear about two weeks after exposure and then improve without complications.

Trial ID:
2026-526160-21-00
Trial Phase:
Therapeutic confirmatory (Phase III)

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