Ibrutinib is a medication used in this clinical trial to provide long-term treatment for patients who have previously benefited from it in earlier studies. It is designed to help manage certain types of blood cancers by interfering with the growth and spread of cancer cells. This trial aims to continue offering ibrutinib to patients who have shown positive results and meet specific criteria.

Follicular Lymphoma – A type of non-Hodgkin lymphoma that usually grows slowly and affects the lymph nodes. It often presents with painless swelling of lymph nodes and can spread to other parts of the body over time.

Chronic Lymphocytic Leukemia – A cancer of the blood and bone marrow that typically progresses slowly. It is characterized by an increase in white blood cells called lymphocytes, which can lead to symptoms like fatigue and swollen lymph nodes.

Waldenstrom Macroglobulinemia – A rare type of cancer that begins in the white blood cells and is characterized by the overproduction of a protein called immunoglobulin M. This can lead to symptoms such as bleeding, vision problems, and neurological issues.

Multiple Myeloma – A cancer of plasma cells in the bone marrow, leading to bone pain, anemia, and kidney dysfunction. It often progresses with the accumulation of abnormal cells in the bone marrow.

Marginal Zone Lymphoma – A type of slow-growing non-Hodgkin lymphoma that originates in the marginal zone of lymphoid tissue. It can affect the spleen, lymph nodes, or other organs and may cause symptoms like swelling and fatigue.

Diffuse Large B-Cell Lymphoma – A fast-growing type of non-Hodgkin lymphoma that can arise in lymph nodes or outside of them. It often presents with rapidly enlarging masses and can spread quickly to other parts of the body.

Urothelial Carcinoma – A cancer that typically occurs in the bladder but can also affect the ureters and kidneys. It is characterized by the abnormal growth of cells in the lining of the urinary tract.

Breast Cancer – A common cancer that forms in the cells of the breasts, often presenting as a lump or mass. It can spread to other parts of the body through the lymphatic system or bloodstream.

Acute Myeloid Leukemia – A fast-growing cancer of the blood and bone marrow characterized by the rapid production of abnormal white blood cells. It can lead to symptoms such as fatigue, fever, and an increased risk of infections.

Graft vs Host Disease – A condition that can occur after a bone marrow or stem cell transplant, where the donated cells attack the recipient’s body. It can affect various organs and tissues, leading to a range of symptoms.

Mantle Cell Lymphoma – A rare type of non-Hodgkin lymphoma that typically affects older adults and is characterized by the overproduction of B-cells. It often presents with swollen lymph nodes and can spread to other parts of the body.