You enter the trial after joining it. The trial is called the VISION Trial and is for people having head and neck reconstruction because of head and neck cancer.

During the operation, your flap, which is a piece of tissue used to rebuild the area, is checked in one of two ways: either with indocyanine green fluorescence imaging or with standard clinical assessment. Standard clinical assessment means the usual doctor checks used to judge blood flow in the flap.

If you are assigned to the imaging group, you receive indocyanine green as a 75 mg dose given by intravenous administration. Intravenous administration means the medicine is given into a vein.

The medicine is supplied as a solution for injection. It is used during the operation to help check flap blood flow.

During the operation, your flap is assessed to see whether it has enough blood flow. This assessment is done either with the imaging method using indocyanine green or with standard clinical methods.

The result of this assessment is used to guide the surgical care of the flap during the operation.

For 1 month after surgery, the trial checks whether there is partial flap loss that requires surgical intervention. Partial flap loss means that part of the tissue used for reconstruction does not survive and needs another operation.

During this same period, the trial also checks for total flap loss, flap-related re-exploration under general anaesthesia, and flap salvage. General anaesthesia means medicine is given so that you are asleep during surgery. Flap salvage means saving the flap after a problem is found.

For 3 months after surgery, the trial records postoperative complications. Postoperative complications means health problems that happen after the operation.

These complications are graded using the Clavien-Dindo classification, which is a system used to describe how serious a complication is.