Comparison of different treatments for follicular lymphoma

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    What is this study about?

    This study involves comparing two treatments for a condition known as follicular or marginal zone lymphoma, both of which are types of cancer affecting lymph cells. The first treatment combines zanubrutinib with an antibody called Anti-CD20, while the second treatment involves lenalidomide and rituximab. These treatments are intended for patients who have not responded or have stopped responding to conventional treatment. One of the primary objectives of the study is to determine which treatment is more effective in preventing the cancer from progressing, referred to as progression-free survival. Additionally, the study aims to assess the impact of these treatments on the patients’ quality of life, evaluating various aspects through questionnaires related to physical and emotional well-being, symptoms, and the ability to perform normal activities.

    Learn more about this Trial

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      Locations

      Where does the clinical trial take place?

      St Poelten , Austria

      Wien , Austria

      Hradec Kralove , Czechia

      Olomouc , Czechia

      Antony , France

      Le Mans , France

      Montpellier Cedex , France

      Paris , France

      Strasbourg , France

      VandoeuvrelesNancy , France

      Aviano , Italy

      Bologna , Italy

      Milano , Italy

      Milano , Italy

      Novara , Italy

      Pavia , Italy

      Reggio Emilia , Italy

      Udine , Italy

      ClujNapoca , Romania

      Iasi , Romania

      Badalona , Spain

      Burgos , Spain

      Cadiz , Spain

      Granada , Spain

      Hospitalet de LLobregat , Spain

      Leon , Spain

      Madrid , Spain

      Madrid , Spain

      Madrid , Spain

      Madrid , Spain

      Madrid , Spain

      Murcia , Spain

      Pamplona , Spain

      Pozuelo de Alarcon , Spain

      Salamanca , Spain

      Sevilla , Spain

      Terassa , Spain

      Huddersfield , United Kingdom

      London , United Kingdom

      Plymouth , United Kingdom

      You can join this study in:

      : !!dwa.

      Netherlands: ‘s-Gravenhage, ‘s-Hertogenbosch, Alkmaar, Almelo, Almere, Amersfoort, Amsterdam, Apeldoorn, Arnhem, Beek, Bergen op Zoom, Beverwijk, Breda, Delft, Deventer, Dirksland, Doetinchem, Dordrecht, Ede, Eindhoven, Enschede, Geleen, Goes, Gouda, Groningen, Haarlem, Harderwijk, Heemstede, Heerlen, Heeze, Helmond, Hilversum, Hoofddorp, Hoogeveen, Hoorn, Leeuwarden, Leiden, Leiden, RC, Leiderdorp, Maastricht, Nieuwegein, Nijmegen, Roermond, Roosendaal, Rotterdam, Sneek, Terneuzen, The Hague, Tiel, Tilburg, Uden, Utrecht, Veldhoven, Venlo, Zaandam, Zutphen, Zwolle.

      Spain: A Coruña, Albacete, Alcalá de Henares, Alcobendas, Alcorcón, Alcoy, Algeciras, Alicante, Almería, Alzira, Ávila, Badajoz, Badalona, Barakaldo, Barcelona, Benalmádena, Bilbao, Boadilla del Monte, Buenos Aires, Burgos, Burjassot, Cáceres, Cádiz, Cartagena, Castellón de la Plana, Castilleja de la Cuesta, Collado Villalba, Córdoba, Coslada, Elche, Esplugues de Llobregat, Ferrol, Fuenlabrada, Galdakao, Gandia, Getafe, Getxo, Gijón, Girona, Granada, Huelva, Jaén, Jerez de la Frontera, L’Hospitalet de Llobregat, Laredo, Las Palmas de Gran Canaria, León, Lleida, Lugo, Madrid, Majadahonda, Málaga, Manises, Manresa, Marbella, Mérida, Móstoles, Murcia, Ourense, Oviedo, Palma, Pamplona, Parla, Ponferrada, Pontevedra, Pozuelo de Alarcón, Puerto De Sagunto, Reus, Rincón de la Victoria, Sabadell, Salamanca, Salt, San Cristóbal de La Laguna, San Pedro Alcántara, San Sebastián, San Sebastián de los Reyes, Sant Adrià de Besòs, Sant Andreu de La Barca, Sant Cugat del Vallès, Sant Cugat del Vallès, Sant Joan d’Alacant, Sant Joan Despí, Santa Cruz de Tenerife, Santander, Santiago de Compostela, Saragossa, Segovia, Seville, Talavera de la Reina, Terrassa, Teruel, Toledo, Tomelloso, Torrejón de Ardoz, Torrevieja, Valencia, Valladolid, Vigo, Villajoyosa, Villamartin, Villareal, Vitoria, Xàtiva, Zamora.

      Denmark: Aabenraa, Aalborg, Aarhus, Copenhagen, Esbjerg, Frederiksberg, Gandrup, Glostrup, Hellerup, Herlev, Herning, Holbæk, Holstebro, Hvidovre, Køge, Kolding, Næstved, Odense, Roskilde, Slagelse, Søborg, Sønderborg, Svendborg, Vejle, Viborg.

      Germany: Aachen, Altenburg, Ansbach, Aschaffenburg, Augsburg, Bad Abbach, Bad Bentheim, Bad Berka, Bad Bramstedt, Bad Doberan, Bad Friedrichshall, Bad Homburg vor der Höhe, Bad Krozingen, Bad Nauheim, Bad Oeynhausen, Bad Reichenhall, Bad Saarow, Bad Schönborn, Bad Soden, Baden, Bamberg, Bayreuth, Bergisch Gladbach, Berlin, Bielefeld, Bitburg, Blankenfelde-Mahlow, Böblingen, Bochum, Bonn, Bottrop, Bramsche, Brandenburg an der Havel, Braunschweig, Bremen, Buxtehude, Chemnitz, Cloppenburg, Coburg, Cologne, Coswig, Cottbus, Dachau, Darmstadt, Datteln, Deggendorf, Deggingen, Delitzsch, Dessau-Roßlau, Donauwörth, Dortmund, Dresden, Duisburg, Dülmen, Düsseldorf, Eggenfelden, Eichstätt, Elsterwerda, Erbach im Odenwald, Erding, Erfurt, Erkelenz, Erlangen, Eschweiler, Essen, Esslingen am Neckar, Flensburg, Frankfurt, Freiburg im Breisgau, Friedrichshafen, Friedrichsthal, Fulda, Fürstenwalde, Fürth, Garmisch-Partenkirchen, Gauting, Geesthacht, Geilenkirchen, Gelnhausen, Georgsmarienhütte, Gera, Giessen, Goch, Gommern, Görlitz, Göttingen, Greifswald, Großhansdorf, Gütersloh, Haar, Hagen, Halle, Hamburg, Hamm, Hanau, Hanover, Heidelberg, Heilbronn, Heinsberg, Hemer, Herne, Hildesheim, Hochheim am Main, Hohenmölsen, Homburg, Hoppegarten, Höxter, Idar-Oberstein, Immenhausen, Immenstadt im Allgäu, Jena, Jerichow, Kaiserslautern, Karlsruhe, Kassel, Kehl, Kempten, Kiel, Kirchheim unter Teck, Koblenz, Konstanz, Krefeld, Kronach, Lahr, Landsberg am Lech, Landshut, Langen, Langenau, Lebach, Leipzig, Lemgo, Leverkusen, Limburg, Lingen, Löhne, Löwenstein, Lübeck, Lüdenscheid, Ludwigsburg, Ludwigshafen, Lüneburg, Magdeburg, Mainz, Mannheim, Marburg, Markkleeberg, Mayen, Memmingen, Merseburg, Meschede, Mettmann, Minden, Moers, Mönchengladbach, Mörfelden-Walldorf, Munich, Münnerstadt, Münster, Mutlangen, Naunhof, Neu-Isenburg, Neumünster, Neuruppin, Neuss, Nordhausen, Northeim, Nuremberg, Nürtingen, Offenbach am Main, Offenburg, Oldenburg, Oldenburg In Holstein, Osnabrück, Paderborn, Papenburg, Passau, Peine, Pforzheim, Pirna, Planegg, Pohlheim, Potsdam, Quedlinburg, Radeberg, Ratingen, Ravensburg, Recklinghausen, Regensburg, Remscheid, Rendsburg, Reutlingen, Rheine, Riesa, Rodewisch, Rosenheim, Rostock, Rüdersdorf, Rüsselsheim am Main, Saarbrücken, Saarlouis, Sande, Sankt Augustin, Schleswig, Schönau am Königssee, Schönebeck, Schwäbisch Hall, Schweinfurt, Schwerin, Selters, Siegburg, Siegen, Simmern, Sindelfingen, Singen, Solingen, Speyer, Stade, Stendal, Stralsund, Stuhr, Stuttgart, Suhl, Sulzbach-Rosenberg, Templin, Torgau, Traunstein, Trier, Troisdorf, Tübingen, Tuttlingen, Ulm, Unterhaching, Velbert, Villingen-Schwenningen, Wallerfing, Wangen im Allgäu, Weiden in der Oberpfalz, Wermsdorf, Wertheim, Wesel, Westerstede, Wiesbaden, Wipperfürth, Witten, Wolfenbüttel, Wolfsburg, Worms, Wuppertal, Würselen, Würzburg, Zwickau.

      Belgium: Aalst, Alken, Anderlecht, Antwerp, Arlon, Ath, Beerzel, Belgium, Beuzet, Bonheiden, Bouge, Brasschaat, Bruges, Brussels, Charleroi, Dendermonde, Edegem, Esneux, Genk, Ghent, Haine-Saint-Paul, Ham-sur-Heure-Nalinnes, Hamme-Mille, Hasselt, Jette, Kortrijk, Leuven, Libramont-Chevigny, Liège, Lier, Linkebeek, Loverval, Lubbeek, Mechelen, Melsbroek, Mol, Mons, Montigny-le-Tilleul, Namur, Noirefontaine, Ostend, Ottignies-Louvain-la-Neuve, Overpelt, Pelt, Roeselare, Saint-Nicolas, Sint-Niklaas, Thuin, Tienen, Tournai, Tubiza, Turnhout, Verviers, West Flanders, Wilrijk, Woluwe-Saint-Lamber, Yvoir, Zaventem.

      United Kingdom: Aberdeen, Airdrie, Barnsley, Barry, Basingstoke, Bath, Bebington, Bedford, Belfast, Bellshill, Birmingham, Blackburn, Blackpool, Bournemouth, Bradford, Brighton and Hove, Bristol, Burton upon Trent, Bury Saint Edmunds, Cambridge, Cannock, Canterbury, Cardiff, Chelmsford, Cheltenham, Chesterfield, Chichester, Chinnor, Chippenham, Chorley, Clydebank, Coatbridge, Colchester, Corby, Cottingham, Coventry, Craigavon, Derby, Doncaster, Dudley, Dundee, Durham, East Kilbride, Eastleigh, Edinburgh, Exeter, Felixstowe, Frimley, Gillingham, Glasgow, Gloucester, Gorleston-on-Sea, Great Yarmouth, Guildford, Hackensack, Harefield, Harlow, Harrow, Hexham, High Wycombe, Hoddesdon, Honiton, Huddersfield, Inverness, Ipswich, Isleworth, Keighley, King’s Lynn, Kingston upon Hull, Lancaster, Leamington Spa, Leeds, Leicester, Lincoln, Liskeard, Liverpool, London, Londonderry, Luton, Macclesfield, Maidstone, Manchester, Middlesbrough, Motherwell, Nantwich, Newcastle upon Tyne, Newmarket, Newquay, Northampton, Norwich, Nottingham, Oswestry, Oxford, Penarth, Penzance, Perth, Peterborough, Plymouth, Poole, Portsmouth, Prescot, Preston, Reading, Redhill, Rhyl, Rochdale, Romford, Rotherham, Salford, Sheffield, Shipley, South Shields, Southampton, Stafford, Stanmore, Stevenage, Stockport, Stockton-on-Tees, Stoke-on-Trent, Sunderland, Sutton, Sutton Coldfield, Sutton-in-Ashfield, Swansea, Swinton, Taunton, Thetford, Torquay, Trowbridge, Truro, Wakefield, Walsall, Warwick, Watford, West Yorkshire, Westbury-on-Trym, Westcliff-on-Sea, Wigan, Winchester, Windsor, Wirral, Wishaw, Withington, Wolverhampton, Wrexham, Wythenshawe, Yate, Yeovil, York.

      Italy: Acquaviva delle Fonti, Alessandria, Ancona, Arezzo, Arzignano, Ascoli Piceno, Avellino, Aviano, Baggiovara, Bari, Bassano del Grappa, Battipaglia, Bellaria – Igea Marina, Bergamo, Bologna, Bolzano, Borgo San Lorenzo, Brescia, Brindisi, Busto Arsizio, Cagliari, Candiolo, Carpi, Carrara, Casatenovo, Caserta, Cassino, Castelfranco Veneto, Castellana Grotte, Catania, Catanzaro, Cefalù, Chieti, Como, Cona, Cosenza, Cremona, Cuneo, Empoli, Faenza, Ferrara, Florence, Foggia, Foligno, Genoa, Grosseto, Gussago, L’Aquila, La Spezia, Lecco, Legnago, Livorno, Lucca, Macerata, Mantua, Massa, Meldola, Messina, Milan, Mirano, Misterbianco, Modena, Monopoli, Monserrato, Montichiari, Monza, Naples, Negrar di Valpolicella, Novara, Orbassano, Padua, Palermo, Parma, Pavia, Perugia, Pesaro, Pescara, Peschiera del Garda, Piacenza, Pietra Ligure, Pisa, Pistoia, Ponderano, Ponte San Pietro, Pordenone, Pozzilli, Pozzuoli, Prato, Ranica, Ravenna, Reggio Calabria, Reggio Emilia, Rho, Rimini, Rionero in Vulture, Rivoli, Rome, Rozzano, Salerno, San Donato Milanese, San Giovanni Rotondo, Sassari, Siena, Sondrio, Statte, Telese Terme, Terni, Torrette, Tradate, Trento, Treviglio, Treviso, Tricase, Trieste, Turin, Udine, Varese, Venice, Vercelli, Verduno, Verona, Vicenza, Viterbo.

      France: Aix-en-Provence, Amiens, Angers, Annecy, Annonay, Antony, Argenteuil, Ars-Laquenexy, Aurillac, Avignon, Bayonne, Beauvais, Besançon, Bobigny, Bois-Guillaume, Bondy, Bordeaux, Boulogne-Billancourt, Boulogne-sur-Mer, Bourg-en-Bresse, Brest, Bron, Caen, Cahors, Caluire-et-Cuire, Cannes, Chambéry, Chambray-lès-Tours, Cholet, Clamart, Clermont-Ferrand, Clichy, Colmar, Colombes, Compiègne, Corbeil-Essonnes, Creil, Créteil, Dax, Dijon, Douai, Dunkirk, Épagny-Metz-Tessy, Garches, Gières, Gonesse, Grenoble, Hyères, La Roche-sur-Yon, La Rochelle, La Tronche, Laquenexy, Le Chesnay, Le Coudray, Le Havre, Le Kremlin-Bicêtre, Le Mans, Le Plessis-Robinson, Le Puy-en-Velay, Libourne, Lille, Limoges, Loos, Lorient, Lyon, Marseille, Martigues, Maubeuge, Meaux, Mont-de-Marsan, Montauban, Montfermeil, Montivilliers, Montpellier, Morlaix, Mougins, Mulhouse, Nancy, Nantes, Neuilly-sur-Seine, Nice, Nîmes, Orléans, Oullins-Pierre-Bénite, Paris, Pau, Perpignan, Pessac, Pierre-Bénite, Plérin, Poissy, Poitiers, Pontoise, Pringy, Quimper, Quint-Fonsegrives, Reims, Rennes, Rodez, Romans-sur-Isère, Roubaix, Rouen, Saint-Brieuc, Saint-Cloud, Saint-Denis, Saint-Étienne, Saint-Grégoire, Saint-Herblain, Saint-Malo, Saint-Mandé, Saint-Ouen-sur-Seine, Saint-Pierre, Saint-Priest-en-Jarez, Saint-Quentin, Salouël, Strasbourg, Suresnes, Toulon, Toulouse, Tours, Trévenans, Vaillant, Val-de-Marne, Valence, Valenciennes, Vannes, Vantoux, Villefranche-sur-Saône, Villejuif, Villeurbanne.

      Portugal: Alcabideche, Almada, Amadora, Aveiro, Braga, Carnaxide, Cascais, Coimbra, Covilhã, Creixomil e Mariz, Faro, Figueira da Foz, Funchal, Guarda, Guimarães, Leiria, Lisbon, Loures, Matosinhos, Paço de Arcos, Ponte De Lima, Portimão, Porto, Porto Covo, Santa Maria da Feira, Senhora da Hora, Setúbal, Torres Novas, Torres Vedras, Viana do Castelo, Vila Nova de Gaia, Vila Nova de Gaia, Vila Real.

      Norway: Ålesund, Bærum, Bergen, Bodø, Drammen, Fredrikstad, Gjøvik, Kalnes, Kristiansand, Lørenskog, Moss, Oslo, Sarpsborg, Skedsmokorset, Stavanger, Tønsberg, Tromsø, Trondheim.

      Greece: Alexandroupolis, Athens, Chaidari, Chortiatis, Corfu, Efkarpia, Exochi, Goudi, Haidari, Heraklion, Holargos, Ioannina, Kallithea, Larissa, Marousi, Mytilene, Nea Ionia, Patras, Piraeus, Pylaia-Chortiatis, Rio, Thessaloniki, Volos.

      Romania: Arad, Bacău, Baia Mare, Bragadiru, Brăila, Brașov, Bucharest, Buzău, Câmpulung, Caracal, Cluj-Napoca, Constanța, Craiova, Deva, Florești, Galați, Hunedoara, Iași, Mangalia, Oradea, Otopeni, Ovidiu, Pitești, Ploiești, Reșca, Sângeorgiu de Mureș, Satu Mare, Sibiu, Suceava, Târgu Mureș, Timișoara.

      Austria: Bad Dürrnberg, Bad Ischl, Bludenz, Braunau am Inn, Bregenz, Eisenstadt, Feldbach, Feldkirch, Graz, Grieskirchen, Innsbruck, Klagenfurt am Wörthersee, Krems an der Donau, Kufstein, Leoben, Linz, Multiple Locations, Rankweil, Salzburg, Sankt Pölten, Sankt Veit an der Glan, Schwaz, Steyr, Stockerau, Vienna, Vöcklabruck, Wals-Siezenheim, Wels, Wiener Neustadt, Zams.

      Hungary: Baja, Balassagyarmat, Balatonfüred, Békéscsaba, Budapest, Csorna, Debrecen, Deszk, Edelény, Eger, Encs, Farkasgyepű, Gödöllő, Gyöngyös, Gyöngyössolymos, Győr, Gyula, Hajdúnánás, Hatvan, Kaposvár, Kistarcsa, Komárom, Mátraháza, Miskolc, Monor, Mosonmagyaróvár, Nyíregyháza, Orosháza, Pécs, Püspökladány, Salgótarján, Sellye, Százhalombatta, Szeged, Székesfehérvár, Szekszárd, Szigetvár, Szolnok, Szombathely, Tatabánya, Törökbálint, Vác, Veszprém, Zalaegerszeg.

      Slovakia: Banská Bystrica, Bardejov, Bojnice, Bratislava, Brezno, Dubnica nad Váhom, Kežmarok, Kláštor pod Znievom, Košice, Levice, Liptovský Mikuláš, Lučenec, Malacky, Martin, Michalovce, Moldava nad Bodvou, Námestovo, Nitra, Nové Zámky, Partizánske, Piešťany, Poprad, Púchov, Rimavská Sobota, Rožňava, Ružomberok, Sabinov, Spišská Nová Ves, Šurany, Svidník, Topoľčany, Trebišov, Trenčín, Trnava, Žilina, Zvolen.

      Poland: Będzin, Bełchatów, Biała Podlaska, Białystok, Bielsko-Biała, Brzozów, Bydgoszcz, Bystra, Bytom, Chęciny, Chełm, Chojnice, Chorzów, Chrzanów, Częstochowa, Dąbrowa Górnicza, Elbląg, Gdańsk, Gdynia, Giżycko, Gliwice, Grodzisk Mazowiecki, Grudziądz, Gryfice, Grzepnica, Inowrocław, Iwonicz-Zdrój, Jelenia Góra, Józefów, Karczew, Katowice, Kędzierzyn Koźle, Kielce, Kłodzko, Knurów, Kobylniki, Konin, Kościan, Koszalin, Ksawerów, Łańcut, Łęczna, Legnica, Leszno, Łódź, Łowicz, Lubin, Lublin, Malbork, Mikołów, Mysłowice, Nadarzyn, Nowa Sól, Nowy Sącz, Nowy Targ, Olsztyn, Opole, Osielsko, Ossy, Ostróda, Ostrowiec Świętokrzyski, Oświęcim, Otwock, Piaseczno, Piła, Piotrków Trybunalski, Poland, Poznań, Prabuty, Przemyśl, Puławy, Racibórz, Radom, Rybnik, Rzeszów, Siedlce, Skarżysko-Kamienna, Skawina, Skierniewice, Skórzewo, Słupsk, Sochaczew, Sopot, Sosnowiec, Środa Wielkopolska, Staszów, Strzelce Opolskie, Świdnica, Szczecin, Szklarska Poręba, Sztum, Tarnów, Tarnowskie Góry, Toruń, Trzebnica, Tychy, Ustroń, Wadowice, Wałbrzych, Warsaw, Wejherowo, Wieliszew, Włocławek, Wrocław, Zabrze, Zamość, Zawadzkie, Zgierz, Żory.

      Czechia: Benešov, Beroun, Bílina, Bílovec, Boskovice, Brandýs nad Labem-Stará Boleslav, Brno, Broumov, České Budějovice, Choceň, Chomutov, Havířov, Havlíčkův Brod, Holešov, Hořovice, Hradec Králové, Jablonec nad Nisou, Jihlava, Jílové u Prahy, Jindřichův Hradec, Klatovy, Klecany, Kolín, Krnov, Kroměříž, Kutná Hora, Kyjov, Liberec, Litovel, Louny, Lovosice, Měšice, Miroslav, Mladá Boleslav, Náchod, Nové Město, Novu00e1 Ves Pod Pleu0161u00ed, Nový Bor, Nový Jičín, Olomouc, Opava, Ostrava, Pardubice, Pilsen, Písek, Polička, Prague, Příbram, Prostějov, Rokycany, Slaný, Slezská Ostrav, Strakonice, Svitavy, Teplice, Trinec, Trutnov, Ústí nad Labem, Varnsdorf, Vsetín, Zlín.

      Bulgaria: Blagoevgrad, Botevgrad, Branipole, Burgas, Cherven Bryag, Dimitrovgrad, Dobrich, Dupnitsa, Gabrovo, Gorna Oryahovitsa, Haskovo, Kardzhali, Kozloduy, Lovech, Montana, Panagyurishte, Pazardzhik, Pernik, Petrich, Pleven, Plovdiv, Razgrad, Ruse, Sevlievo, Shumen, Silistra, Sliven, Smolyan, Sofia, Stara Zagora, Troyan, Tsarev Brod, Varna, Veliko Tarnovo, Velingrad, Vidin, Vratsa.

      Sweden: Borås, Botkyrka, Danderyd, Eskilstuna, Falun, Gävle, Gothenburg, Halmstad, Helsingborg, Huddinge, Jönköping, Kalmar, Karlstad, Kristianstad, Lidingö, Linköping, Luleå, Lund, Malmö, Mölndal, Mölnlycke, Motala, Örebro, Östersund, Rättvik, Skövde, Solna, Stockholm, Sundsvall, Trollhättan, Umeå, Uppsala, Varberg, Växjö.

      Slovenia: Celje, Golnik, Jesenice, Kamnik, Ljubljana.

      Albania: Durrës, Elbasan, Korçë, Tirana.

      Finland: Espoo, Hämeenlinna, Helsinki, Järvenpää, Kokkola, Kuopio, Lahti, Oulu, Pori, Seinäjoki, Tampere, Turku, Vaasa.


      Study Steps

      How Complex Will My Study Be and What Phases Will I Go Through?

      The steps a patient needs to take in this clinical trial depend on the arm group they are allocated to. Here’s a general outline based on the interventions detailed in the armsInterventionsModule of the clinical trial:

      1. Follicular Lymphoma Arm A: Zanubrutinib plus Obinutuzumab (Experimental):

        1. Participants will receive a combination of the drugs zanubrutinib and obinutuzumab.
        2. After completing the combination treatment, participants will continue receiving zanubrutinib monotherapy.
        3. This monotherapy will continue until any of the following occurs: confirmed disease progression, unacceptable toxicity, withdrawal of consent, or study termination.
      2. Follicular Lymphoma Arm B: Lenalidomide plus Rituximab (Active Comparator):

        1. Participants will receive a combination of the drugs lenalidomide and rituximab.
      3. The description for the subsequent steps for this arm was not provided in the quoted section, but the general approach is similar to the previously mentioned experimental arm, often involving continuous treatment until specific endpoints are reached.

        If you are participating in the trial, you will be given more detailed instructions and information about the dosing schedule, mode of administration, and any monitoring or assessments that will be part of your treatment regimen. Please note that this outline is not exhaustive, and specific details may vary based on individual patient circumstances and trial protocols.


      Diseases Under Investigation

      What Conditions Qualify Me for This Study?

      To join the study, you need to have a histologically confirmed grade 1-3a follicular lymphoma (FL) or marginal zone lymphoma (MZL).


      Terms and conditions

      What Requirements I Have to Meet To Join This Study?

      When Am I Eligible to Join the Study?

      Here are the conditions you must meet to join the study, along with explanations for medical terms:

      1. Histologically confirmed grade 1-3a Follicular Lymphoma (FL) or Marginal Zone Lymphoma (MZL): This means that your lymphoma must be diagnosed through microscopic examination of tissue and be classified as grade 1, 2, or 3a. Grades 1-3a indicate the speed of lymphoma progression, with higher grades usually having more rapid progression.
      2. Previously received ≥1 line of systemic therapy including anti-CD20 agent: You must have been treated before with at least one type of systemic therapy, which affects the whole body, such as chemotherapy. This therapy must have included an anti-CD20 agent, which is a drug targeting the CD20 protein on the surface of B-cells, common in certain types of lymphoma.
      3. Documented failure to achieve at least partial response during the most recent systemic therapy or documented progressive disease after the most recent systemic therapy: There must be medical records indicating that your last systemic therapy didn’t result in at least a partial reduction of lymphoma (partial response), or that the lymphoma continued to grow (progressive disease) despite therapy.
      4. Need for systemic therapy for FL or MZL: You must be in a condition that requires further systemic treatment for your lymphoma.
      5. Measurable disease by computed tomography or magnetic resonance imaging: The lymphoma must be visible and measurable on medical imaging tests like CT scans or MRI scans, which allow doctors to see inside the body and measure the size of lymphoma.
      6. Adequate bone marrow, liver and renal function: Your bone marrow (which produces blood cells), liver (which processes drugs and removes toxins), and kidneys (which remove waste from the blood and regulate fluid balance) must be functioning well enough to handle the treatments involved in the trial.

      What Reasons Could Exclude Me from the Study?

      Exclusion Criteria:

      1. Transformation to aggressive lymphoma: This refers to a change from a less aggressive or indolent form of lymphoma to a more aggressive form, which would make participation in the study inappropriate.
      2. Requiring ongoing need for corticosteroid treatment: If you are currently dependent on corticosteroids for treatment, you may be ineligible to participate.
      3. Clinically significant cardiovascular disease: This includes conditions like heart failure, recent heart attack, severe arrhythmia, or any other heart condition that could affect patient safety or study results.
      4. Prior malignancy within the past 2 years: If you have had another type of cancer within the last two years, other than successfully treated non-melanoma skin cancer or another specific non-life-threatening cancer, you may be excluded.
      5. Active fungal, bacterial, and/or viral infection that requires systemic therapy: If you have a serious infection that needs system-wide treatment like oral or intravenous antibiotics, antifungals, or antivirals, you may not be able to participate.

      Please note that additional Inclusion/Exclusion criteria defined by the study protocol may also apply.


      Investigational Medicinal Product

      What Products Are Being Used in This Study?

      The drugs involved in this study are:

      1. Zanubrutinib (BGB-3111): Zanubrutinib is a small molecule inhibitor of Bruton’s tyrosine kinase (BTK) which is involved in the signaling of the B-cell receptor pathway. This pathway influences the survival and proliferation of B-cells, and BTK inhibitors like zanubrutinib are used as targeted therapies for various B-cell malignancies.
      2. Rituximab: Rituximab is a monoclonal antibody that targets the CD20 protein found on the surface of B-cells. It is used to treat certain autoimmune diseases and types of cancer, particularly non-Hodgkin’s lymphoma and chronic lymphocytic leukemia. It works by marking B-cells for destruction by one’s own immune system.
      3. Lenalidomide: Lenalidomide is an immunomodulatory drug that affects the immune system and can also prevent the development of new blood vessels that tumors need to grow (anti-angiogenesis). It is used primarily in the treatment of multiple myeloma and certain myelodysplastic syndromes.
      4. Obinutuzumab: Obinutuzumab is a monoclonal antibody designed for the treatment of certain types of blood cancers. It targets the CD20 protein present on B-cells like rituximab but has been modified to induce a stronger immune response when binding to CD20, potentially leading to more effective destruction of cancerous cells.

      Both Zanubrutinib and its trade name Brukinsa, as well as the active substances for all other drugs, are mentioned .

      Have the Medicinal Substances Used in the Trial Been Previously Studied in Medicine?

      The active substances participating in the clinical trial are:

      1. Zanubrutinib: Zanubrutinib is known to the medical literature under the name BGB-3111 or commercial name Brukinsa. It will be administered orally as capsules in repeated 28-day cycles for the treatment of lymphoma.
      2. Rituximab: Rituximab is a well-known medication in the medical field and is commonly referred to as Rituxan, MabThera, Ruxience, or Truxima. It will be administered intravenously on a specified schedule during the first 5 cycles of treatment.
      3. Lenalidomide: Known commercially as Revlimid, lenalidomide is an established drug that will be administered orally as capsules once a day on Days 1 to 21 of each 28-day cycle for a total of 12 cycles.
      4. Obinutuzumab: Obinutuzumab will be administered at a specified dose on certain days of the treatment cycles to participants in this trial.

      All of these substances are known to medicine and have been mentioned in medical literature, being involved in the treatment of various conditions including types of lymphomas for which this trial is being conducted.


      Study ID

      CT-EU-00057161

      Recruitment status

      Recruting new patients

      Start of the trial

      2 years ago