This study focuses on individuals treated with CAR-T cells, a type of immunotherapy used to fight certain cancers. Specifically, the research involves patients with B-cell acute lymphoblastic leukemia, a type of blood cancer, or B-cell lymphoma, a cancer of the immune system. Following this treatment, patients may be at a higher risk for infections. The purpose of the study is to compare two different ways to prevent these infections.
One method being studied is immunoglobulin replacement therapy, which involves the administration of human normal immunoglobulin through an intravenous line, meaning it is delivered directly into a vein. The other method is antibiotic prophylaxis, which is the use of medications to prevent infections before they occur. The medications used for comparison in this study include amoxicillin trihydrate, sulfamethoxazole, trimethoprim, bromhexine hydrochloride, levofloxacin, amoxicillin sodium, and azithromycin.
Participants in the study will be assigned to one of the two prevention methods. During the follow-up period, which lasts for 12 months, the occurrence of infections will be monitored. This includes looking for recurrent infections that require treatment or severe infections that lead to a hospital stay.
France 
