An exploratory study to evaluate the effect of rimonabant on hand function in patients with cervical spinal cord injury

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What is this study about?

This study focuses on individuals living with a spinal cord injury, which is damage to the bundle of nerves that sends signals between the brain and the rest of the body. The research specifically looks at people with injuries in the neck area, known as cervical spinal cord injury. The goal of this study is to evaluate the effect of rimonabant on improving how well the hands work.

Participants in this research will take rimonabant in the form of tablets. During the course of the study, various measurements will be taken to observe changes in hand strength, movement, and coordination. Other aspects of physical health, such as walking ability, balance, and fatigue, may also be monitored to understand how the medication affects the body overall.

Who Can Join the Study?

You must be between 18 and 75 years old.
It must have been at least 2 months since your spinal cord injury, which is damage to the bundle of nerves that carries messages between your brain and your body.
You must have an injury to the cervical spine, which refers to the area of the neck that protects the spinal cord.
Your injury must be classified as AIS A–D, which is a way doctors measure the level of sensory and motor function (the ability to feel sensations and move muscles) remaining after an injury.
Your muscle strength must be between 5 and 40 points on the UEMS score, which is a specific scale used by doctors to measure the strength of individual muscles.
You must be able to provide informed consent, meaning you understand the details of the study and agree to participate.

Who Cannot Join the Study?

Having a high risk of suicide as measured by a specific screening tool called the C-SSRS.
Taking part in another medical study involving drugs (medicines) within one month before joining this study.
Having any health condition that the doctor believes makes it unsafe to participate, such as severe heart failure (a condition where the heart cannot pump enough blood) or uncontrolled diabetes (high blood sugar that is not being properly managed).
Having reasons why you cannot undergo transcranial magnetic stimulation (TMS), which is a medical procedure that uses magnetic fields to stimulate nerve cells. This includes having metal implants in the head, a pacemaker (a device used to control the heartbeat), having epileptic seizures (sudden electrical disturbances in the brain) in the last two years, or having other implanted electronic devices.
A history of serious psychiatric disorders (mental health conditions), major depression, or previous suicide attempts.
Using anticoagulants (medicines that thin the blood to prevent clots) or medications that affect how the body processes certain drugs, known as CYP3A4 inhibitors or inducers.
A Body Mass Index (BMI) higher than 40 kg/m², which is a measure used to determine if a person’s weight is high relative to their height.
Being pregnant or breastfeeding.
Being a man or woman who is able to have children but cannot promise to use highly effective contraceptive methods (birth control that has a failure rate of less than 1% per year).
Having uncontrolled hypothyroidism (a condition where the thyroid gland does not produce enough hormones), or a history of serious bone, liver, or kidney disease.
Being unable to come to the hospital for scheduled visits.
Having a known allergy to rimonabant (the medicine being studied) or any of the excipients (the inactive ingredients used to make the medicine).

Where you can join this trial?

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Other Sites

Site Name	City	Country	Status
Hcrohdvx Nslnipbo Du Pdfnzfrezcrh	Toledo	Spain

Trial status

Country	Status	Recruitment Start
Spain	Recruiting	02.03.2026

Trial locations

Rimonabant is being tested to see if it can help improve how people with injuries to the spinal cord in their neck use their hands.

Investigated diseases:

Spinal cord injury cervical

Spinal cord injury – This condition occurs when there is damage to the spinal cord, which is the bundle of nerves that carries messages between the brain and the rest of the body. The injury can be caused by physical trauma or other internal factors. Depending on the location and severity, it can disrupt the transmission of nerve signals. This disruption often leads to a loss of movement, sensation, or coordination in the parts of the body below the site of the injury. The level of the injury determines which bodily functions are most affected.

Trial ID:

2025-524279-22-00

Protocol code:

RIMOHANDOPEN

Trial Phase:

Human Pharmacology (Phase I) – Other

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An exploratory study to evaluate the effect of rimonabant on hand function in patients with cervical spinal cord injury

What is this study about?

Who Can Join the Study?

Who Cannot Join the Study?