This study focuses on patients with an open abdomen, a condition where the abdominal wall is left open after surgery instead of being closed immediately. The purpose of the study is to evaluate whether early administration of botulinum toxin type a – haemagglutinin complex helps in the primary midline closure, which is the process of bringing the edges of the muscle layers together during surgery. This medication, also known as DYSPORT, is given through an intramuscular injection, which is a shot delivered directly into the muscle.

During the study, participants will receive either the study medication or a placebo. The process involves observing how well the abdominal muscles can be stitched together within a specific timeframe. Researchers will monitor for various factors, such as the time it takes for the muscle layers to close and the possibility of developing an incisional hernia, which is a protrusion of tissue through the surgical site. The study also tracks potential side effects, such as muscle weakness or reactions at the site of the injection, as well as respiratory issues or infections at the surgery location.