This study is being conducted to investigate the efficacy and safety of orforglipron in individuals living with Peripheral Artery Disease. This condition involves narrowed or blocked blood vessels, which can reduce blood flow to the limbs. The study compares the effects of the experimental tablet against a placebo.

Participants will be assigned to different groups to receive either orforglipron or a placebo once daily by oral use. During the study, the ability to walk a certain distance will be monitored to see how the medication affects movement and physical activity over time.