A study to evaluate the effectiveness and safety of lebrikizumab in adults with nummular eczema who do not respond well to topical corticosteroids.

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What is this study about?

This study focuses on Nummular Dermatitis, a skin condition that causes itchy, coin-shaped patches on the skin. The research aims to evaluate the efficacy and safety of lebrikizumab, which is an injectable medication, compared to a placebo. This study is intended for adults whose condition is not well-managed by topical corticosteroids, which are medicated creams or ointments applied directly to the skin.

Participants in the study will receive either lebrikizumab or a placebo via a subcutaneous injection, which is a method of delivering medication into the fatty layer just under the skin. The study includes a period where participants are monitored for 24 weeks, followed by an extension phase. During the trial, changes in pruritus, which is the medical term for itching, and the overall impact of the skin condition on daily life will be observed.

Who Can Join the Study?

  • You must be an adult, which means you are 18 years of age or older at the time of the initial screening.
  • You must have been diagnosed with nummular eczema (a skin condition that causes itchy, coin-shaped patches) by a doctor.
  • You must have shown signs or symptoms (physical indicators or feelings of the condition) of nummular eczema for at least 6 months before the study begins.
  • You must be able to understand the purpose and risks of the study and be willing to follow all the rules and steps of the research plan.
  • You must be able to provide written informed consent, which is a formal document you sign to show you understand the study and agree to participate.

Who Cannot Join the Study?

  • Having a history or current presence of moderate-to-severe atopic dermatitis, which is a common type of skin inflammation, measured by an EASI score (an assessment tool used to measure the severity of skin disease) of 16 or higher.
  • Having any skin disease other than nummular eczema (a type of skin inflammation that causes coin-shaped spots) or mild atopic dermatitis that might make it difficult to measure the results of the study, such as psoriasis (a condition that causes red, itchy, and scaly patches) or other forms of eczema.
  • Having any skin signs that look like psoriasis, such as nail pitting (small dents in the fingernails or toenails), or having issues on the scalp, palms, soles of the feet, or skin folds, as well as having a personal or family history of psoriasis or psoriatic arthritis (a type of arthritis that affects people who have psoriasis).
  • A history of anaphylaxis, which is a severe and potentially life-threatening allergic reaction.
  • Being pregnant, breastfeeding, or planning to become pregnant or breastfeed during the study period.
  • Having a known sensitivity or allergy to any of the ingredients used to make the study medication.
  • Being required to live in or be part of an institution due to an order from judicial (court-related) or administrative (government-related) authorities.

Where you can join this trial?

Verified and Recommended Sites

No sites found in this category

Verified Sites

Site Name City Country Status
Technische Universitaet Dresden Dresden Germany
Studienzentrum Dr. Beate Schwarz Langenau Germany
ICMR (International Center for Medical Research) Madrid Spain
Gyncentrum Sp. z o.o. Katowice Poland
IRCCS Humanitas Research Hospital Rozzano Italy
Centre Hospitalier Universitaire De Lille Lille France
Oncopole Claudius Regaud Toulouse France

Other Sites

Site Name City Country Status
Accellacare Espana S.L. Alcobendas Spain
Dkc Fokus-5 Lzip OOD Sofia Bulgaria
Klinische Forschung Osnabrueck Osnabrück Germany
Azienda Universitaria Ospedaliera Consorziale Policlinico Bari Bari Italy
Hautarztpraxis Dr. Med. Matthias Hoffmann Witten Germany
Centre Hospitalier Le Mans Le Mans France
Kdamxfax Onuzpxdvy Azo Oldenburg In Holstein Germany
Ddqpmijmay Aqw Caxqpghlkl Cxsblp Xykcxpvrzvdl Eoeu Sofia Bulgaria
Mbbhups Cejtqh Fxpxjsuvpj Ecqx Sofia Bulgaria
Ujpkszkkniedetexzgcqz Sdfngmeqitbabxjcvd Abr Kiel Germany
Ahnawrf Unduq Ldqcsz Spbrs Srgpiidev N 8 Bvflew Vicenza Italy
Srdmz Swm z okbr Lodz Poland
Trdsnpgmawk uan Stzllzhbqlc Bfblfnmo Gthk Bad Bentheim Germany
Hfcakuvl Uuabitxhqreef Bnbdrqh Bilbao Spain
Hvppilrc Mivpux Bvxxi Dm Lj Vulf Jotnjb Villajoyosa Spain
Cufvfrlk Rfyaharn Cibiun Sug z opcw Mzmagkq spnqk Poznan Poland
Hrjdjkql Gtupgvj Dc Gwisqcydze Granollers Spain
Kdnosyjk Bukgzmfmp gwnao Bielefeld Germany
Dyjbpkxheyq Aaw Cmirdfydroi Cavebx Pnyhsn Ecfn Plovdiv Bulgaria
Ctkcnjd Nzljkjelbyid Txqwjlf Dqazu Lviqhm Snz z ossu Cracow Poland
Gvmxwrhjwmgyaavyovr Wpjwimbauprjf Augsburg Germany
Hcyvc Rknwodaubynljpnovvvmsb ewul Berlin Germany
Drrgyraqd Svq z ompe Wroclaw Poland
Kbjcbxmc Dulwdfjiz Ggzz Darmstadt Germany
Dxtaiuyzpkwntr Hftbnxm Geym Hamburg Germany
Fiztnhehapibfb Gcjrptvooazdwmcwyij fhff Dnppbqcgtzcn Uch Vcvjkwriolb Azsuepfjxzso Ucgczquvmhkkd Lmoxafyyzpuv Gkc Blankenfelde-Mahlow Germany
Cscxwdcxys Pwyyskmjkbm Ldmomgwenmhjorvwceisbqn Mroqfopu sjsvn Wroclaw Poland
Upumgqupkewmssktilmph Twfcykmcb Aiz Tuebingen Germany
Mgohdfv Casehq &bwpzpl Umsqlqbfwd Oq Fjvkrbyd Freiburg Im Breisgau Germany
Gugbsi Ubnhutejzq Fcysiwllk Frankfurt Germany
Cyekmodtet Rdbcderf sne z ovmy Skierniewice Poland
Vlsxvf dgz Rmplu Uhhlvckjtt Hinyxozq Sevilla Spain
Udbbeabbmg Dbcjg Sypjf Dg Bryfafn Brescia Italy
Fcetkrrtr Pzka Lj Iebpfikjtxfju Bzxwvmgql Dga Haviwnvz Ukuizkenmymoz Lp Ply Madrid Spain
Mqpw samw Iffno Canyjvasou Afci Pnmtvyht Swbsgdxwbjr Grodzisk Mazowiecki Poland
Dtqjiucrnobqohfbdgiogmq cbplrt “tneeuyxglqvszra Elvl Sofia Bulgaria
Efk Lyxrqu Lublin Poland
Dimlanzqut Sqb z orgc Wroclaw Poland
Talwm Ppfdinmesve Pblthyfnrs Ctczjwr Micjieet Svh z oozp Poznan Poland
Fbagpuuzzy Ikdhn Ca Ghhbna Oxjphcuw Mngexqoq Ptbelmqknww Milan Italy
Apesrbd Odikpjjrxgj Ugxjvxifuazpw Ftvjrucr Io Dm Nmoims Naples Italy
Icbllj Izhrxqbt Fkprrsrunjfdu Ofuwiqcykim Rome Italy
Akwdjni Okuolpgcqnr Dc Pffsmls Perugia Italy
Letlvmu Shzhgfqrzsgqyzv Gaqipsz Drwqdmyyopilivo Lublin Poland
Dlovxwuyinue Qmioi Mainz Germany
Zegoxaf Mou Smb z ojiy Kielce Poland
Afsy – Iquzo &ldnqdu Stos Ast Vkrtljjk Dhohmcbd Sofia Bulgaria
Hvq Sxwmcr Apac Toulon France
Hvibrvrv Dchca Nauy Romans-Sur-Isere France
Cnfycm Huktnjcgkko Lnbm Sfe Pierre Benite France

Want to learn more about this study or check if you can participate? Contact us.

Trial status

Country Status Recruitment Start
Bulgaria Bulgaria
Recruiting
24.04.2026
France France
Recruiting
24.04.2026
Germany Germany
Recruiting
24.04.2026
Italy Italy
Recruiting
24.04.2026
Poland Poland
Recruiting
24.04.2026
Spain Spain
Recruiting
24.04.2026

Trial locations

Investigated Drugs:

Lebrikizumab is a medication given as a way to help treat eczema by targeting specific parts of the immune system that cause skin inflammation. It is administered through an injection under the skin.

Nummular Dermatitis – This condition is characterized by the appearance of coin-shaped patches on the skin. These patches can be dry, scaly, or even crusty. The skin in these areas may feel very itchy and inflamed. As the condition progresses, the spots may weep fluid or become thicker. The patches often appear on the arms or legs.

Trial ID:
2025-522403-17-00
Protocol code:
M-27501-30
Trial Phase:
Therapeutic confirmatory (Phase III)

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