A study to evaluate the effectiveness and safety of lebrikizumab in adults with nummular eczema who do not respond well to topical corticosteroids.

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What is this study about?

This study focuses on Nummular Dermatitis, a skin condition that causes itchy, coin-shaped patches on the skin. The research aims to evaluate the efficacy and safety of lebrikizumab, which is an injectable medication, compared to a placebo. This study is intended for adults whose condition is not well-managed by topical corticosteroids, which are medicated creams or ointments applied directly to the skin.

Participants in the study will receive either lebrikizumab or a placebo via a subcutaneous injection, which is a method of delivering medication into the fatty layer just under the skin. The study includes a period where participants are monitored for 24 weeks, followed by an extension phase. During the trial, changes in pruritus, which is the medical term for itching, and the overall impact of the skin condition on daily life will be observed.

Who Can Join the Study?

  • You must be an adult, which means you are 18 years of age or older at the time of the initial screening.
  • You must have been diagnosed with nummular eczema (a skin condition that causes itchy, coin-shaped patches) by a doctor.
  • You must have shown signs or symptoms (physical indicators or feelings of the condition) of nummular eczema for at least 6 months before the study begins.
  • You must be able to understand the purpose and risks of the study and be willing to follow all the rules and steps of the research plan.
  • You must be able to provide written informed consent, which is a formal document you sign to show you understand the study and agree to participate.

Who Cannot Join the Study?

  • Having a history or current presence of moderate-to-severe atopic dermatitis, which is a common type of skin inflammation, measured by an EASI score (an assessment tool used to measure the severity of skin disease) of 16 or higher.
  • Having any skin disease other than nummular eczema (a type of skin inflammation that causes coin-shaped spots) or mild atopic dermatitis that might make it difficult to measure the results of the study, such as psoriasis (a condition that causes red, itchy, and scaly patches) or other forms of eczema.
  • Having any skin signs that look like psoriasis, such as nail pitting (small dents in the fingernails or toenails), or having issues on the scalp, palms, soles of the feet, or skin folds, as well as having a personal or family history of psoriasis or psoriatic arthritis (a type of arthritis that affects people who have psoriasis).
  • A history of anaphylaxis, which is a severe and potentially life-threatening allergic reaction.
  • Being pregnant, breastfeeding, or planning to become pregnant or breastfeed during the study period.
  • Having a known sensitivity or allergy to any of the ingredients used to make the study medication.
  • Being required to live in or be part of an institution due to an order from judicial (court-related) or administrative (government-related) authorities.

Where you can join this trial?

Verified and Recommended Sites

No sites found in this category

Verified Sites

Site Name City Country Status
Technische Universitaet Dresden Dresden Germany
Studienzentrum Dr. Beate Schwarz Langenau Germany
ICMR (International Center for Medical Research) Madrid Spain
Gyncentrum Sp. z o.o. Katowice Poland
IRCCS Humanitas Research Hospital Rozzano Italy
Centre Hospitalier Universitaire De Lille Lille France
Oncopole Claudius Regaud Toulouse France

Other Sites

Site Name City Country Status
Accellacare Espana S.L. Alcobendas Spain
Dkc Fokus-5 Lzip OOD Sofia Bulgaria
Klinische Forschung Osnabrueck Osnabrück Germany
Azienda Universitaria Ospedaliera Consorziale Policlinico Bari Bari Italy
Hautarztpraxis Dr. Med. Matthias Hoffmann Witten Germany
Centre Hospitalier Le Mans Le Mans France
Kafwnsfj Orphjjclx Aga Oldenburg In Holstein Germany
Dbusegvpam Aei Cpjhrhdywe Cmbbbk Xnlyjnaxxmia Eexd Sofia Bulgaria
Mlkmctk Cfnzej Fjqpgqmkgi Eait Sofia Bulgaria
Urryjgxnnpxgpncblbcux Sxndxgujknhrsnovzr Ajn Kiel Germany
Adxaaic Uppwi Lftuce Snnzr Slmriozej N 8 Bydqss Vicenza Italy
Sfvig Ssp z omyf Lodz Poland
Tfleqlrcrpx upt Srudeexqgda Bhzeuieg Gcry Bad Bentheim Germany
Hnmwdexj Umjeuvjauztfh Bwrcbro Bilbao Spain
Huawhlwj Mjfupo Bbbdo Dw Lv Vpvm Jiiryx Villajoyosa Spain
Ckcqlses Rrlqystq Cniotn Szi z ogyz Mdyolhr sqvjs Poznan Poland
Hwyzzexh Grjplgn Db Gbmbwaehpx Granollers Spain
Kazaefit Bdoyqcwao gsqbq Bielefeld Germany
Dxsxyuphkpj Akq Cfrngldesnn Cvcdso Pvtvbr Eocq Plovdiv Bulgaria
Clsnvhd Nwtcpaxhvvpq Txccnew Dsmxs Lqokrw Suf z osli Cracow Poland
Gvvcusruqpzymrdyzfm Wdcrjmnyabntw Augsburg Germany
Hojze Rkiqanlhaiwitchpcemjah ewri Berlin Germany
Dwzmgnbvh Scz z ohyu Wroclaw Poland
Kerasiih Dhqjfqxmv Gfdc Darmstadt Germany
Dilputpkfpqipo Hsgczff Givi Hamburg Germany
Fsqbvghyzhuzsg Gbehkptqsknffizkezl fmct Dgntdrdrotlk Usl Valafmaoiyx Aqfhenwnhxrv Ukhkmfxbdisys Lnogealjhcdz Gzg Blankenfelde-Mahlow Germany
Cuslqzwudk Pypjvnmkbeh Lwkthahuyxtsafxelwtzqmc Mfofgyhq stfdv Wroclaw Poland
Uhdqlvuwehbdobmxmctci Txsrqklwl Afh Tuebingen Germany
Mkesmau Ctvmer &oozwiw Ujwzkbsxpd Ox Ftzyuhgo Freiburg Im Breisgau Germany
Gefrrk Uoheydiuvl Fepmpjtfm Frankfurt Germany
Czqcffzrrv Rktxysoq szt z oclt Skierniewice Poland
Vjtxyj dcn Rnhgo Uvqszvoihk Hroqiyuh Sevilla Spain
Uvttjemvap Dqgrd Sppbu Dr Bbhgeqd Brescia Italy
Furgkqzhk Pfxd Lc Irlyftcxigxqk Bdqvatpvu Dda Hcyfhohk Ujghlcdksjpbi Lz Ppm Madrid Spain
Meqe speq Iyunr Cnuzggsygn Anyy Puxywkso Syfjgqgreab Grodzisk Mazowiecki Poland
Ddwxjmmufdbwqcskaajtmrp cbdmew “firkiyfybaccfbt Ejjm Sofia Bulgaria
Ehm Lqzyap Lublin Poland
Dcmblepfuc Scp z ouhg Wroclaw Poland
Tdjso Pptrqhmbeym Pecuzbxpqn Cpnylgq Mqildzdy Saa z owno Poznan Poland
Fotuavgkej Icour Cg Gpfbio Onhszktc Mafvctrb Pbbggujbkny Milan Italy
Aimkrul Okvjirhsrjr Udjajcirgdykd Fmfdolqs Il Dz Nqjele Naples Italy
Ieecsh Iowpdnnp Fowjarlzvwxsz Otsyovjfnrh Rome Italy
Acnfwap Oflfgaxoqci Dy Pohwljx Perugia Italy
Lwxvgkd Soaaqghfwekngvo Gqthmxh Dtklgxnbdpophag Lublin Poland
Dexnhhivyacw Qcsix Mainz Germany
Zvpbqmt Mnh Sxi z ojhs Kielce Poland
Aglj – Imgct &jzwjht Sndw Anx Vqomlaol Dlsynngj Sofia Bulgaria
Hvl Sufjhp Aolr Toulon France
Hgwzsdab Dsgpz Nhjm Romans-Sur-Isere France
Chukqa Hnrzddtxzpj Lqod Stc Pierre Benite France

Want to learn more about this study or check if you can participate? Contact us.

Trial status

Country Status Recruitment Start
Bulgaria Bulgaria
Recruiting
24.04.2026
France France
Recruiting
24.04.2026
Germany Germany
Recruiting
24.04.2026
Italy Italy
Recruiting
24.04.2026
Poland Poland
Recruiting
24.04.2026
Spain Spain
Recruiting
24.04.2026

Trial locations

Investigated Drugs:

Lebrikizumab is a medication given as a way to help treat eczema by targeting specific parts of the immune system that cause skin inflammation. It is administered through an injection under the skin.

Nummular Dermatitis – This condition is characterized by the appearance of coin-shaped patches on the skin. These patches can be dry, scaly, or even crusty. The skin in these areas may feel very itchy and inflamed. As the condition progresses, the spots may weep fluid or become thicker. The patches often appear on the arms or legs.

Trial ID:
2025-522403-17-00
Protocol code:
M-27501-30
Trial Phase:
Therapeutic confirmatory (Phase III)

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